Chinese medicine formula DSQRL versus glucocorticoids for the treatment of experimental pulmonary fibrosis

Hong Qi ZHANG*, Yu Fung Yau, Man Sin Wong, Oi Yan Man, Ying Ying He, Nickie Chan, Min LI

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Pulmonary fibrosis (PF) is a devastating interstitial lung disease that may develop idiopathically or as a complication of many other diseases. The outcome of the current main treatment by glucocorticoids is by no means satisfactory. This study has tested a new Chinese medicine Decoction for Strengthening Qi and Replenishing Lung (DSQRL) for the treatment of experimental PF in comparison with prednisolone. Eighty-five rats with PF induced by CCl4 were randomly divided into 4 groups to undertake treatment either by (a) high dose of prednisolone; (b) Chinese medicine formula DSQRL; (c) combined treatment of the above two; or (d) sham feeding of water in equal volume. At the end of 60 days treatment, the DSQRL treatment achieved a significantly better outcome than prednisolone in terms of general behavior, histological examination, hydroxyproline content of the lung and inflammatory cell counts in bronchoalveolar lavage fluid. Thus, the newly proposed Chinese medicinal formula DSQRL appears to be a better and promising option for PF than glucocorticoids for the treatment of PF.

Original languageEnglish
Pages (from-to)318-324
Number of pages7
JournalJournal of Ethnopharmacology
Volume116
Issue number2
DOIs
Publication statusPublished - 5 Mar 2008

Scopus Subject Areas

  • Pharmacology
  • Drug Discovery

User-Defined Keywords

  • Chinese medicine
  • Prednisolone
  • Pulmonary fibrosis
  • Rat

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