Chinese Herbal Medicine for Reducing Chemotherapy-Associated Side-Effects in Breast Cancer Patients: A Systematic Review and Meta-Analysis

Sha Li; Tsz Him So; Guoyi Tang; Hor Yue Tan; Ning Wang; Bacon Fung Leung Ng; Chris Kam Wa Chan; Edwin Chau Leung Yu; Yibin Feng

doi:10.3389/fonc.2020.599073

Chinese Herbal Medicine for Reducing Chemotherapy-Associated Side-Effects in Breast Cancer Patients: A Systematic Review and Meta-Analysis

Sha Li, Tsz Him So, Guoyi Tang, Hor Yue Tan, Ning Wang, Bacon Fung Leung Ng, Chris Kam Wa Chan, Edwin Chau Leung Yu^*, Yibin Feng^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

28 Citations (Scopus)

Abstract

Background: Chemotherapy usually induces a variety of side-effects in cancer treatment as it cannot tell normal cells apart from cancer cells and kills both. Chinese herbal medicine (CHM) has been regarded as a potential effective intervention for relieving the side-effects of chemotherapy in breast cancer patients.

Objective: This study aims to conduct a comprehensive systematic review and meta-analysis to evaluate the efficacy of CHM as adjuvant therapy for reducing the chemotherapy-induced side-effects in the treatment of breast cancer.

Methods: Main electronic databases were searched up to May 2020 for Randomized Controlled Trials (RCTs) evaluating the effect of CHM on breast cancer patients with chemotherapy. The PRISMA statement was adopted in this study and meta-analyses were performed.

Results: The included studies showed unsatisfied quality. Results based on available literature indicated that the adjunctive use of CHM with chemotherapy may reduce the chemotherapeutic agents-associated adverse events, including nausea and vomiting, diarrhea, alopecia, myelosuppression, and impaired immune function.

Conclusion: A confident conclusion could not be have due to the lack of large scale and high quality trials.

Original language	English
Article number	599073
Number of pages	20
Journal	Frontiers in Oncology
Volume	10
DOIs	https://doi.org/10.3389/fonc.2020.599073
Publication status	Published - 9 Dec 2020

Scopus Subject Areas

Medicine(all)
Complementary and alternative medicine
Oncology
Epidemiology

User-Defined Keywords

breast cancer
chemotherapy
herbal medicine
meta-analysis
side effect

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fonc.2020.599073

Cite this

@article{6bc35203d65645168cf5aa2089facc8a,

title = "Chinese Herbal Medicine for Reducing Chemotherapy-Associated Side-Effects in Breast Cancer Patients: A Systematic Review and Meta-Analysis",

abstract = "Background: Chemotherapy usually induces a variety of side-effects in cancer treatment as it cannot tell normal cells apart from cancer cells and kills both. Chinese herbal medicine (CHM) has been regarded as a potential effective intervention for relieving the side-effects of chemotherapy in breast cancer patients.Objective: This study aims to conduct a comprehensive systematic review and meta-analysis to evaluate the efficacy of CHM as adjuvant therapy for reducing the chemotherapy-induced side-effects in the treatment of breast cancer.Methods: Main electronic databases were searched up to May 2020 for Randomized Controlled Trials (RCTs) evaluating the effect of CHM on breast cancer patients with chemotherapy. The PRISMA statement was adopted in this study and meta-analyses were performed.Results: The included studies showed unsatisfied quality. Results based on available literature indicated that the adjunctive use of CHM with chemotherapy may reduce the chemotherapeutic agents-associated adverse events, including nausea and vomiting, diarrhea, alopecia, myelosuppression, and impaired immune function.Conclusion: A confident conclusion could not be have due to the lack of large scale and high quality trials.",

keywords = "breast cancer, chemotherapy, herbal medicine, meta-analysis, side effect",

author = "Sha Li and So, {Tsz Him} and Guoyi Tang and Tan, {Hor Yue} and Ning Wang and Ng, {Bacon Fung Leung} and Chan, {Chris Kam Wa} and Yu, {Edwin Chau Leung} and Yibin Feng",

note = "Funding Information: The study was financially supported by Innovation and Technology Commission: The 2nd Phase of Integrative Joint Organizational Platform (IJOP) Disease Collaborative Panel (Project Code: 200009062), Wong{\textquoteright}s Donation (Project Code: 200006276), the Gaia Family Trust for Modern Oncology of Chinese Medicine (Project Code: 200007008), Research Grant Council, HKSAR (Project Code RGC GRF 17152116), and Health and Medical Research Fund (Project Codes 15162961, 16172751 and 17181101). Publisher Copyright: {\textcopyright} 2020 Li, So, Tang, Tan, Wang, Ng, Chan, Yu and Feng.",

year = "2020",

month = dec,

day = "9",

doi = "10.3389/fonc.2020.599073",

language = "English",

volume = "10",

journal = "Frontiers in Oncology",

issn = "2234-943X",

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TY - JOUR

T1 - Chinese Herbal Medicine for Reducing Chemotherapy-Associated Side-Effects in Breast Cancer Patients

T2 - A Systematic Review and Meta-Analysis

AU - Li, Sha

AU - So, Tsz Him

AU - Tang, Guoyi

AU - Tan, Hor Yue

AU - Wang, Ning

AU - Ng, Bacon Fung Leung

AU - Chan, Chris Kam Wa

AU - Yu, Edwin Chau Leung

AU - Feng, Yibin

N1 - Funding Information: The study was financially supported by Innovation and Technology Commission: The 2nd Phase of Integrative Joint Organizational Platform (IJOP) Disease Collaborative Panel (Project Code: 200009062), Wong’s Donation (Project Code: 200006276), the Gaia Family Trust for Modern Oncology of Chinese Medicine (Project Code: 200007008), Research Grant Council, HKSAR (Project Code RGC GRF 17152116), and Health and Medical Research Fund (Project Codes 15162961, 16172751 and 17181101). Publisher Copyright: © 2020 Li, So, Tang, Tan, Wang, Ng, Chan, Yu and Feng.

PY - 2020/12/9

Y1 - 2020/12/9

N2 - Background: Chemotherapy usually induces a variety of side-effects in cancer treatment as it cannot tell normal cells apart from cancer cells and kills both. Chinese herbal medicine (CHM) has been regarded as a potential effective intervention for relieving the side-effects of chemotherapy in breast cancer patients.Objective: This study aims to conduct a comprehensive systematic review and meta-analysis to evaluate the efficacy of CHM as adjuvant therapy for reducing the chemotherapy-induced side-effects in the treatment of breast cancer.Methods: Main electronic databases were searched up to May 2020 for Randomized Controlled Trials (RCTs) evaluating the effect of CHM on breast cancer patients with chemotherapy. The PRISMA statement was adopted in this study and meta-analyses were performed.Results: The included studies showed unsatisfied quality. Results based on available literature indicated that the adjunctive use of CHM with chemotherapy may reduce the chemotherapeutic agents-associated adverse events, including nausea and vomiting, diarrhea, alopecia, myelosuppression, and impaired immune function.Conclusion: A confident conclusion could not be have due to the lack of large scale and high quality trials.

AB - Background: Chemotherapy usually induces a variety of side-effects in cancer treatment as it cannot tell normal cells apart from cancer cells and kills both. Chinese herbal medicine (CHM) has been regarded as a potential effective intervention for relieving the side-effects of chemotherapy in breast cancer patients.Objective: This study aims to conduct a comprehensive systematic review and meta-analysis to evaluate the efficacy of CHM as adjuvant therapy for reducing the chemotherapy-induced side-effects in the treatment of breast cancer.Methods: Main electronic databases were searched up to May 2020 for Randomized Controlled Trials (RCTs) evaluating the effect of CHM on breast cancer patients with chemotherapy. The PRISMA statement was adopted in this study and meta-analyses were performed.Results: The included studies showed unsatisfied quality. Results based on available literature indicated that the adjunctive use of CHM with chemotherapy may reduce the chemotherapeutic agents-associated adverse events, including nausea and vomiting, diarrhea, alopecia, myelosuppression, and impaired immune function.Conclusion: A confident conclusion could not be have due to the lack of large scale and high quality trials.

KW - breast cancer

KW - chemotherapy

KW - herbal medicine

KW - meta-analysis

KW - side effect

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DO - 10.3389/fonc.2020.599073

M3 - Journal article

C2 - 33363030

AN - SCOPUS:85098149782

SN - 2234-943X

VL - 10

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - 599073

ER -

Chinese Herbal Medicine for Reducing Chemotherapy-Associated Side-Effects in Breast Cancer Patients: A Systematic Review and Meta-Analysis

Abstract

Scopus Subject Areas

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UN SDGs

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