TY - JOUR
T1 - Chemical modifications of nucleic acid aptamers for therapeutic purposes
AU - Ni, Shuaijian
AU - Yao, Houzong
AU - Wang, Lili
AU - Lu, Jun
AU - Jiang, Feng
AU - LYU, Aiping
AU - ZHANG, Ge
N1 - Funding Information:
We thank the other academic staff members in Aiping Lu and Ge Zhang?s group at Hong Kong Baptist University (Hong Kong, China). We also thank Hong Kong Baptist University (Hong Kong, China) and the State Key Laboratory of Bioorganic and Natural Products Chemistry (Shanghai, China) for providing critical comments and technical support. This study was supported by the Hong Kong General Research Fund (HKBU12102914 to Ge Zhang), the Faculty Research Grant of Hong Kong Baptist University (FRG2/12-13/027 to Ge Zhang) and Open Project of Shanghai Institute of Organic Chemistry (SKLBNPC17344 to Feng Jiang).
PY - 2017/8/2
Y1 - 2017/8/2
N2 - Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss methods to conquer these challenges and highlight recent developments of chemical modifications and technological advances that may enable early aptamers to be translated into clinical therapeutics.
AB - Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss methods to conquer these challenges and highlight recent developments of chemical modifications and technological advances that may enable early aptamers to be translated into clinical therapeutics.
KW - Binding affinity
KW - Chemical modification
KW - Nuclease degradation
KW - Nucleic acid aptamer
KW - Rapid excretion
UR - http://www.scopus.com/inward/record.url?scp=85026830070&partnerID=8YFLogxK
U2 - 10.3390/ijms18081683
DO - 10.3390/ijms18081683
M3 - Review article
C2 - 28767098
AN - SCOPUS:85026830070
SN - 1661-6596
VL - 18
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 8
M1 - 1683
ER -