Chemical modifications of nucleic acid aptamers for therapeutic purposes

Shuaijian Ni, Houzong Yao, Lili Wang, Jun Lu, Feng Jiang*, Aiping LYU, Ge ZHANG

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

225 Citations (Scopus)


Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss methods to conquer these challenges and highlight recent developments of chemical modifications and technological advances that may enable early aptamers to be translated into clinical therapeutics.

Original languageEnglish
Article number1683
JournalInternational Journal of Molecular Sciences
Issue number8
Publication statusPublished - 2 Aug 2017

Scopus Subject Areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

User-Defined Keywords

  • Binding affinity
  • Chemical modification
  • Nuclease degradation
  • Nucleic acid aptamer
  • Rapid excretion


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