Chemical modifications of nucleic acid aptamers for therapeutic purposes

Shuaijian Ni; Houzong Yao; Lili Wang; Jun Lu; Feng Jiang; Aiping LYU; Ge ZHANG

doi:10.3390/ijms18081683

Chemical modifications of nucleic acid aptamers for therapeutic purposes

Shuaijian Ni, Houzong Yao, Lili Wang, Jun Lu, Feng Jiang^*, Aiping LYU, Ge ZHANG

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Review article › peer-review

199 Citations (Scopus)

Abstract

Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss methods to conquer these challenges and highlight recent developments of chemical modifications and technological advances that may enable early aptamers to be translated into clinical therapeutics.

Original language	English
Article number	1683
Journal	International Journal of Molecular Sciences
Volume	18
Issue number	8
DOIs	https://doi.org/10.3390/ijms18081683
Publication status	Published - 2 Aug 2017

Scopus Subject Areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

User-Defined Keywords

Binding affinity
Chemical modification
Nuclease degradation
Nucleic acid aptamer
Rapid excretion

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10.3390/ijms18081683

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title = "Chemical modifications of nucleic acid aptamers for therapeutic purposes",

abstract = "Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss methods to conquer these challenges and highlight recent developments of chemical modifications and technological advances that may enable early aptamers to be translated into clinical therapeutics.",

keywords = "Binding affinity, Chemical modification, Nuclease degradation, Nucleic acid aptamer, Rapid excretion",

author = "Shuaijian Ni and Houzong Yao and Lili Wang and Jun Lu and Feng Jiang and Aiping LYU and Ge ZHANG",

note = "Funding Information: We thank the other academic staff members in Aiping Lu and Ge Zhang?s group at Hong Kong Baptist University (Hong Kong, China). We also thank Hong Kong Baptist University (Hong Kong, China) and the State Key Laboratory of Bioorganic and Natural Products Chemistry (Shanghai, China) for providing critical comments and technical support. This study was supported by the Hong Kong General Research Fund (HKBU12102914 to Ge Zhang), the Faculty Research Grant of Hong Kong Baptist University (FRG2/12-13/027 to Ge Zhang) and Open Project of Shanghai Institute of Organic Chemistry (SKLBNPC17344 to Feng Jiang).",

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AU - Ni, Shuaijian

AU - Yao, Houzong

AU - Wang, Lili

AU - Lu, Jun

AU - Jiang, Feng

AU - LYU, Aiping

AU - ZHANG, Ge

N1 - Funding Information: We thank the other academic staff members in Aiping Lu and Ge Zhang?s group at Hong Kong Baptist University (Hong Kong, China). We also thank Hong Kong Baptist University (Hong Kong, China) and the State Key Laboratory of Bioorganic and Natural Products Chemistry (Shanghai, China) for providing critical comments and technical support. This study was supported by the Hong Kong General Research Fund (HKBU12102914 to Ge Zhang), the Faculty Research Grant of Hong Kong Baptist University (FRG2/12-13/027 to Ge Zhang) and Open Project of Shanghai Institute of Organic Chemistry (SKLBNPC17344 to Feng Jiang).

PY - 2017/8/2

Y1 - 2017/8/2

N2 - Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss methods to conquer these challenges and highlight recent developments of chemical modifications and technological advances that may enable early aptamers to be translated into clinical therapeutics.

AB - Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss methods to conquer these challenges and highlight recent developments of chemical modifications and technological advances that may enable early aptamers to be translated into clinical therapeutics.

KW - Binding affinity

KW - Chemical modification

KW - Nuclease degradation

KW - Nucleic acid aptamer

KW - Rapid excretion

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U2 - 10.3390/ijms18081683

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JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

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Chemical modifications of nucleic acid aptamers for therapeutic purposes

Abstract

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