Chemical identity and cardiovascular toxicity of hydrophobic organic components in PM2.5

Zenghua Qi, Yanhao Zhang, Zhi Feng Chen, Chun Yang, Yuanyuan Song, Xiaoliang Liao, Weiquan Li, Suk Ying Tsang, Guoguang Liu, Zongwei Cai*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

42 Citations (Scopus)


Numerous experimental and epidemiological studies have demonstrated that exposure to PM2.5 may result in pathogenesis of several major cardiovascular diseases (CVDs), which can be attributed to the combined adverse effects induced by the complicated components of PM2.5. Organic materials, which are major components of PM2.5, contain thousands of chemicals, and most of them are environmental hazards. However, the contamination profile and contribution to overall toxicity of PM2.5-bound organic components (OCs) have not been thoroughly evaluated yet. Herein, we aim to provide an overview of the literature on PM2.5-bound hydrophobic OCs, with an emphasis on the chemical identity and reported impairments on the cardiovascular system, including the potential exposure routes and mechanisms. We first provide an update on the worldwide mass concentration and composition data of PM2.5, and then, review the contamination profile of PM2.5-bound hydrophobic OCs, including constitution, concentration, distribution, formation, source, and identification. In particular, the link between exposure to PM2.5-bound hydrophobic OCs and CVDs and its possible underlying mechanisms are discussed to evaluate the possible risks of PM2.5-bound hydrophobic OCs on the cardiovascular system and to provide suggestions for future studies.

Original languageEnglish
Article number110827
JournalEcotoxicology and Environmental Safety
Publication statusPublished - 15 Sept 2020

Scopus Subject Areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

User-Defined Keywords

  • Cardiovascular toxicity
  • Contamination profile
  • Hydrophobic organic components
  • Mechanisms
  • PM


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