TY - JOUR
T1 - Chemical identity and cardiovascular toxicity of hydrophobic organic components in PM2.5
AU - Qi, Zenghua
AU - Zhang, Yanhao
AU - Chen, Zhi Feng
AU - Yang, Chun
AU - Song, Yuanyuan
AU - Liao, Xiaoliang
AU - Li, Weiquan
AU - Tsang, Suk Ying
AU - Liu, Guoguang
AU - Cai, Zongwei
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China ( 21806025 and 91543202 ), the Natural Science Foundation of Guangdong Province ( 2019A1515011294 ), Special Research Program of Ministry of Science and Technology of China ( 2017YFE0191000 ), and Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program ( 2017BT01Z032 ).
PY - 2020/9/15
Y1 - 2020/9/15
N2 - Numerous experimental and epidemiological studies have demonstrated that exposure to PM2.5 may result in pathogenesis of several major cardiovascular diseases (CVDs), which can be attributed to the combined adverse effects induced by the complicated components of PM2.5. Organic materials, which are major components of PM2.5, contain thousands of chemicals, and most of them are environmental hazards. However, the contamination profile and contribution to overall toxicity of PM2.5-bound organic components (OCs) have not been thoroughly evaluated yet. Herein, we aim to provide an overview of the literature on PM2.5-bound hydrophobic OCs, with an emphasis on the chemical identity and reported impairments on the cardiovascular system, including the potential exposure routes and mechanisms. We first provide an update on the worldwide mass concentration and composition data of PM2.5, and then, review the contamination profile of PM2.5-bound hydrophobic OCs, including constitution, concentration, distribution, formation, source, and identification. In particular, the link between exposure to PM2.5-bound hydrophobic OCs and CVDs and its possible underlying mechanisms are discussed to evaluate the possible risks of PM2.5-bound hydrophobic OCs on the cardiovascular system and to provide suggestions for future studies.
AB - Numerous experimental and epidemiological studies have demonstrated that exposure to PM2.5 may result in pathogenesis of several major cardiovascular diseases (CVDs), which can be attributed to the combined adverse effects induced by the complicated components of PM2.5. Organic materials, which are major components of PM2.5, contain thousands of chemicals, and most of them are environmental hazards. However, the contamination profile and contribution to overall toxicity of PM2.5-bound organic components (OCs) have not been thoroughly evaluated yet. Herein, we aim to provide an overview of the literature on PM2.5-bound hydrophobic OCs, with an emphasis on the chemical identity and reported impairments on the cardiovascular system, including the potential exposure routes and mechanisms. We first provide an update on the worldwide mass concentration and composition data of PM2.5, and then, review the contamination profile of PM2.5-bound hydrophobic OCs, including constitution, concentration, distribution, formation, source, and identification. In particular, the link between exposure to PM2.5-bound hydrophobic OCs and CVDs and its possible underlying mechanisms are discussed to evaluate the possible risks of PM2.5-bound hydrophobic OCs on the cardiovascular system and to provide suggestions for future studies.
KW - Cardiovascular toxicity
KW - Contamination profile
KW - Hydrophobic organic components
KW - Mechanisms
KW - PM
UR - http://www.scopus.com/inward/record.url?scp=85086166682&partnerID=8YFLogxK
U2 - 10.1016/j.ecoenv.2020.110827
DO - 10.1016/j.ecoenv.2020.110827
M3 - Review article
C2 - 32535366
AN - SCOPUS:85086166682
SN - 0147-6513
VL - 201
JO - Ecotoxicology and Environmental Safety
JF - Ecotoxicology and Environmental Safety
M1 - 110827
ER -
