Chemical constituents from Xylosma longifolia and their anti-tubercular activity

Bich Ngan Truong; Van Cuong Pham; Huong Doan Thi Mai; Van Hung Nguyen; Manh Cuong Nguyen; Hiêp Tien Nguyen; Hong Jie Zhang; Harry H.S. Fong; Scott G. Franzblau; Djaja D. Soejarto; Van Minh Chau

doi:10.1016/j.phytol.2011.04.008

Chemical constituents from Xylosma longifolia and their anti-tubercular activity

Bich Ngan Truong, Van Cuong Pham^*, Huong Doan Thi Mai, Van Hung Nguyen, Manh Cuong Nguyen, Hiêp Tien Nguyen, Hong Jie Zhang, Harry H.S. Fong, Scott G. Franzblau, Djaja D. Soejarto, Van Minh Chau^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Two new glucosides, 3-methoxy-4-hydroxyphenylpropane-7,8-(6′-benzoyl- 2′,1′-O-β-glucopyranosyl)-7,8,9-trio (1), and 2-hydroxyphenyl-4-caffeoyl-β-d-glucoside (2), together with seven known compounds were isolated from the stem bark of Xylosma longifolia (Flacourtiaceae). The structures of the isolates were established on the basis of their spectral data, including mass spectrometry and 2D-NMR. The compound 8-hydroxy-6-methoxy-pentylisocoumarin (3) exhibited an MIC value of 40.5 μg/mL against M. tuberculosis.

Original language	English
Pages (from-to)	250-253
Number of pages	4
Journal	Phytochemistry Letters
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/j.phytol.2011.04.008
Publication status	Published - Sept 2011

Scopus Subject Areas

Biotechnology
Biochemistry
Agronomy and Crop Science
Plant Science

User-Defined Keywords

8-Hydroxy-6-methoxy- pentylisocoumarin
Anti-tuberculosis
Flacourtiaceae
Xylongoside
Xylosma longifolia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytol.2011.04.008

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@article{ef015fd811764e7681a20ca553b11a6a,

title = "Chemical constituents from Xylosma longifolia and their anti-tubercular activity",

abstract = "Two new glucosides, 3-methoxy-4-hydroxyphenylpropane-7,8-(6′-benzoyl- 2′,1′-O-β-glucopyranosyl)-7,8,9-trio (1), and 2-hydroxyphenyl-4-caffeoyl-β-d-glucoside (2), together with seven known compounds were isolated from the stem bark of Xylosma longifolia (Flacourtiaceae). The structures of the isolates were established on the basis of their spectral data, including mass spectrometry and 2D-NMR. The compound 8-hydroxy-6-methoxy-pentylisocoumarin (3) exhibited an MIC value of 40.5 μg/mL against M. tuberculosis.",

keywords = "8-Hydroxy-6-methoxy- pentylisocoumarin, Anti-tuberculosis, Flacourtiaceae, Xylongoside, Xylosma longifolia",

author = "Truong, {Bich Ngan} and Pham, {Van Cuong} and Mai, {Huong Doan Thi} and Nguyen, {Van Hung} and Nguyen, {Manh Cuong} and Nguyen, {Hi{\^e}p Tien} and Zhang, {Hong Jie} and Fong, {Harry H.S.} and Franzblau, {Scott G.} and Soejarto, {Djaja D.} and Chau, {Van Minh}",

note = "Funding Information: The authors express their thanks to the Director of Cuc Phuong National Park for the permission and auspices in the collection and recollection of samples of X. longifolia. This research was supported under the ICBG grants from the Fogarty International Center, NIH, 1-UO1-TW001015-01 (1998–2003) and 2-UO1-TW001015-06 (2003–2008) through funds from NIH, NSF, and USDA FAS. ",

year = "2011",

month = sep,

doi = "10.1016/j.phytol.2011.04.008",

language = "English",

volume = "4",

pages = "250--253",

journal = "Phytochemistry Letters",

issn = "1874-3900",

publisher = "Elsevier BV",

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T1 - Chemical constituents from Xylosma longifolia and their anti-tubercular activity

AU - Truong, Bich Ngan

AU - Pham, Van Cuong

AU - Mai, Huong Doan Thi

AU - Nguyen, Van Hung

AU - Nguyen, Manh Cuong

AU - Nguyen, Hiêp Tien

AU - Zhang, Hong Jie

AU - Fong, Harry H.S.

AU - Franzblau, Scott G.

AU - Soejarto, Djaja D.

AU - Chau, Van Minh

N1 - Funding Information: The authors express their thanks to the Director of Cuc Phuong National Park for the permission and auspices in the collection and recollection of samples of X. longifolia. This research was supported under the ICBG grants from the Fogarty International Center, NIH, 1-UO1-TW001015-01 (1998–2003) and 2-UO1-TW001015-06 (2003–2008) through funds from NIH, NSF, and USDA FAS.

PY - 2011/9

Y1 - 2011/9

N2 - Two new glucosides, 3-methoxy-4-hydroxyphenylpropane-7,8-(6′-benzoyl- 2′,1′-O-β-glucopyranosyl)-7,8,9-trio (1), and 2-hydroxyphenyl-4-caffeoyl-β-d-glucoside (2), together with seven known compounds were isolated from the stem bark of Xylosma longifolia (Flacourtiaceae). The structures of the isolates were established on the basis of their spectral data, including mass spectrometry and 2D-NMR. The compound 8-hydroxy-6-methoxy-pentylisocoumarin (3) exhibited an MIC value of 40.5 μg/mL against M. tuberculosis.

AB - Two new glucosides, 3-methoxy-4-hydroxyphenylpropane-7,8-(6′-benzoyl- 2′,1′-O-β-glucopyranosyl)-7,8,9-trio (1), and 2-hydroxyphenyl-4-caffeoyl-β-d-glucoside (2), together with seven known compounds were isolated from the stem bark of Xylosma longifolia (Flacourtiaceae). The structures of the isolates were established on the basis of their spectral data, including mass spectrometry and 2D-NMR. The compound 8-hydroxy-6-methoxy-pentylisocoumarin (3) exhibited an MIC value of 40.5 μg/mL against M. tuberculosis.

KW - 8-Hydroxy-6-methoxy- pentylisocoumarin

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KW - Flacourtiaceae

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KW - Xylosma longifolia

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Chemical constituents from Xylosma longifolia and their anti-tubercular activity

Abstract

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