Characterization of Mirabilis antiviral protein - A ribosome inactivating protein from Mirabilis jalapa L.

Ricky N S WONG*, T. B. Ng, S. H. Chan, T. X. Dong, H. W. Yeung

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

17 Citations (Scopus)

Abstract

A protein was purified from root tubers of Mirabilis jalapa to homogeneity by ion-exchange chromatography on CM-Sepharose CL-6B and FPLC on Mono-S column. The purified protein was confirmed to be Mirabilis antiviral protein (MAP). However, in addition to its antiviral property, the MAP was demonstrated to possess abortifacient activity in pregnant mice, inhibitory effect on cell-free protein synthesis and antiproliferative effect on tumor cells. As judged from its biological and physiochemical properties, MAP is a type I ribosome-inactivating protein.

Original languageEnglish
Pages (from-to)585-593
Number of pages9
JournalBiochemistry International
Volume28
Issue number4
Publication statusPublished - 1992

Scopus Subject Areas

  • Biochemistry

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