Abstract
Olfactory glomeruli constitute the first stage of central odor processing. Yet, their role in integration of odor information is only partially understood. We previously discovered that 5 Hz olfactory nerve (ON) stimulation induces long-term depression (LTD) in young (P5 to P8) mice. The present experiments were designed to understand in more detail the molecular mechanisms underlying ON LTD. Bath application of DHPG, a selective group I mGluR agonist, induced ON LTD and occluded subsequent 5Hz stimulation-induced LTD. ON LTD was not induced by activation of group II or III mGluR agonists. The DHPG-induced ON LTD was mediated by mGluR1 but not by mGluR5 because it was antagonized by the mGluR1 antagonist LY367385 but not by the mGluR5 antagonist MPEP. Expression of DHPG-induced ON LTD was accompanied by an increase in paired-pulse ratio suggesting that ON LTD is caused by a decrease of release probability. We propose that mGluR1 is expressed at the ON. ON LTD may be important for establishment and maintenance of odor maps in the olfactory bulb but may also involve in the regulation of the sensitivity for specific odorants.
| Original language | English |
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| Pages (from-to) | S107-S107 |
| Number of pages | 1 |
| Journal | Neuroscience Research |
| Volume | 55 |
| Issue number | Supp. 1 |
| Publication status | Published - 19 Jul 2006 |
| Event | 29th Annual Meeting of the Japan Neuroscience Society, Neuroscience 2006 - Kyoto, Japan Duration: 19 Jul 2006 → 21 Jul 2006 https://www.sciencedirect.com/journal/neuroscience-research/vol/55/suppl/S1 (Conference Abstract) |