Characterization and quantitative analysis of xanthones in gamboges

Quan Bin Han, Jing Zheng Song, Chun Feng Qiao, Hong Xi Xu*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

9 Citations (Scopus)


Aim: To characterize and quantitatively analyze the xanthones in gamboges. Method: A simple and rapid HPLC method was used. Results: Seven major xanthones of gamboges were characterized to be isomorellic acid (1), morellic acid (2), isogambogenic acid (3), gambogenic acid (5), isogambogic acid (6), gambogic acid (7), and 30-hydroxygambogic acid (4) by LC/ESI-MS, respectively. The validation of the quantitative method was performed accordingly. Seven samples from different regions of China and India were examined. They showed similar chromatographic patterns in the HPLC fingerprints, containing the above-mentioned seven major constituents as the characteristic markers. The relative retention time and relative peak area of these characteristic peaks were calculated and set as important parameters for the fingerprinting identification of gamboges. Conclusion: This is a simple, rapid, and efficient quality-control method for the gamboges.
Original languageEnglish
Pages (from-to)210-214
Number of pages5
JournalChinese Journal of Natural Medicines
Issue number3
Publication statusPublished - May 2006

Scopus Subject Areas

  • Drug Discovery
  • Complementary and alternative medicine

User-Defined Keywords

  • Characterization analysis
  • Gamboge
  • Garcinia hanburyi
  • Quantitative analysis
  • Xanthones


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