TY - JOUR
T1 - Changes in the brain intrinsic organization in both on-task state and post-task resting state
AU - Wang, Zhijiang
AU - LIU, Jiming
AU - Zhong, Ning
AU - Qin, Yulin
AU - Zhou, Haiyan
AU - Li, Kuncheng
N1 - Funding Information:
The authors are grateful to the anonymous referees for their significant and constructive comments and suggestions, which greatly improved the paper. The authors are also grateful to Dr. Yong He and Dr. Michelle Hampson who kindly discussed some issues on fMRI techniques with us and Dr. Cherry Romano who polished the paper carefully. The work is partially supported by the National Natural Science Foundation of China under grant no. 60875075 , Beijing Natural Science Foundation (no. 4102007 ) and Beijing University of Technology Doctoral Foundation Project (no. 52007999200701 ).
PY - 2012/8/1
Y1 - 2012/8/1
N2 - The dynamic and robust characteristics of intrinsic functional connectivity of coherent spontaneous activity are critical for the brain functional stability and flexibility. Studies have demonstrated modulation of intrinsic connectivity within local spatial patterns during or after task performance, such as the default mode network (DMN) and task-specific networks. Moreover, recent studies have compared the global spatial pattern in different tasks or over time. However, it is still unclear how the large-scale intrinsic connectivity varies during and after a task. To better understand this issue, we conducted a functional MRI experiment over three sequential periods: an active semantic-matching task period and two rest periods, before and after the task respectively (namely, on-task state and pre-/post-task resting states), to detect task-driven effect on the dynamic large-scale intrinsic organization in both on-task state and post-task resting state. Three hierarchical levels were investigated, including (a) the whole brain small-world topology, (b) the whole pairwise functional connectivity patterns both within the DMN and between the DMN and other regions (i.e., the global/full DMN topography), and (c) the DMN nodal graph properties. The major findings are: (1) The large-scale small-world configuration of brain functional organization is robust, regardless of the behavioral state changing, while it varies adaptively with significantly higher local efficiency and lower global efficiency during the on-task state (P< 0.05, Monte-Carlo corrected); (2) The DMN may be essentially engaged during both task and post-task processes with adaptively varied spatial patterns and nodal graph properties. The present study provides further insights into the robustness and plasticity of the brain intrinsic organization over states, which may be the basis of memory and learning in the brain.
AB - The dynamic and robust characteristics of intrinsic functional connectivity of coherent spontaneous activity are critical for the brain functional stability and flexibility. Studies have demonstrated modulation of intrinsic connectivity within local spatial patterns during or after task performance, such as the default mode network (DMN) and task-specific networks. Moreover, recent studies have compared the global spatial pattern in different tasks or over time. However, it is still unclear how the large-scale intrinsic connectivity varies during and after a task. To better understand this issue, we conducted a functional MRI experiment over three sequential periods: an active semantic-matching task period and two rest periods, before and after the task respectively (namely, on-task state and pre-/post-task resting states), to detect task-driven effect on the dynamic large-scale intrinsic organization in both on-task state and post-task resting state. Three hierarchical levels were investigated, including (a) the whole brain small-world topology, (b) the whole pairwise functional connectivity patterns both within the DMN and between the DMN and other regions (i.e., the global/full DMN topography), and (c) the DMN nodal graph properties. The major findings are: (1) The large-scale small-world configuration of brain functional organization is robust, regardless of the behavioral state changing, while it varies adaptively with significantly higher local efficiency and lower global efficiency during the on-task state (P< 0.05, Monte-Carlo corrected); (2) The DMN may be essentially engaged during both task and post-task processes with adaptively varied spatial patterns and nodal graph properties. The present study provides further insights into the robustness and plasticity of the brain intrinsic organization over states, which may be the basis of memory and learning in the brain.
KW - Default mode network
KW - Modulation
KW - Small world
KW - Task-driven states
KW - Topology
UR - http://www.scopus.com/inward/record.url?scp=84861601492&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2012.04.051
DO - 10.1016/j.neuroimage.2012.04.051
M3 - Journal article
C2 - 22569542
AN - SCOPUS:84861601492
SN - 1053-8119
VL - 62
SP - 394
EP - 407
JO - NeuroImage
JF - NeuroImage
IS - 1
ER -