TY - JOUR
T1 - Cerebral Targeting of Acupuncture at Combined Acupoints in Treating Essential Hypertension
T2 - An Rs-fMRI Study and Curative Effect Evidence
AU - Wang, Yanjie
AU - Zheng, Yu
AU - Qu, Shanshan
AU - Zhang, Jiping
AU - Zhong, Zheng
AU - Zhang, Jialing
AU - Huang, Huanlin
AU - Li, Miaokeng
AU - Xu, Yiwen
AU - Chen, Junqi
AU - Wang, Lei
AU - Steiner, Genevieve Zara
AU - Tang, Chunzhi
AU - Huang, Yong
N1 - Funding Information:
This study was supported by the National Key Basic Research and Development Project (973 Program), Grant no. 2012CB518504. The authors are very grateful to the volunteers and staff from the MRI Center of the First Affiliated Hospital of Guangzhou University of Chinese Medicine in China.
Publisher Copyright:
© 2016 Yanjie Wang et al.
PY - 2016/1
Y1 - 2016/1
N2 - The study attempted to explore that the synergistic effect of acupoints combination is not a simple superposition of single acupoint's effect by comparing and analyzing the changes of blood pressure (BP), SF-36, and brain regions after acupuncture treatment. 47 patients were randomly divided into LR3+KI3 group, LR3 group, and KI3 group. Subjects received Rs-fMRI scan, BP measurement, and SF-36 questionnaires before and after treatment and short-term acupuncture treatment. After treatment, there were no significant differences in BP and SF-36 among 3 groups, compared to the case before treatment, SBP of 3 groups decreased, and DBP significantly decreased while vitality and mental health significantly increased in LR3+KI3 group. Both number and scopes of changes of brain regions in LR3+KI3 group were the largest, which mainly included BAs 3, 4, 8, 19, 21, 24, 32, 44, and 45. In conclusion, acupuncture at LR3+KI3 may auxiliarily reduce BP and improve the vitality and mental health of patients, and the changes of brain regions were related to somatesthesia, movement, vision, audition, emotion and mood, language, memory, etc. BAs 4, 9, 10, 24, 31, 32, and 46 may be the targeting brain areas of acupuncture in assisting hypotension. It is suggested that acupoints combination of LR3+KI3 maybe generates a synergistic effect, and it is not simple sum of single acupoint effect.
AB - The study attempted to explore that the synergistic effect of acupoints combination is not a simple superposition of single acupoint's effect by comparing and analyzing the changes of blood pressure (BP), SF-36, and brain regions after acupuncture treatment. 47 patients were randomly divided into LR3+KI3 group, LR3 group, and KI3 group. Subjects received Rs-fMRI scan, BP measurement, and SF-36 questionnaires before and after treatment and short-term acupuncture treatment. After treatment, there were no significant differences in BP and SF-36 among 3 groups, compared to the case before treatment, SBP of 3 groups decreased, and DBP significantly decreased while vitality and mental health significantly increased in LR3+KI3 group. Both number and scopes of changes of brain regions in LR3+KI3 group were the largest, which mainly included BAs 3, 4, 8, 19, 21, 24, 32, 44, and 45. In conclusion, acupuncture at LR3+KI3 may auxiliarily reduce BP and improve the vitality and mental health of patients, and the changes of brain regions were related to somatesthesia, movement, vision, audition, emotion and mood, language, memory, etc. BAs 4, 9, 10, 24, 31, 32, and 46 may be the targeting brain areas of acupuncture in assisting hypotension. It is suggested that acupoints combination of LR3+KI3 maybe generates a synergistic effect, and it is not simple sum of single acupoint effect.
UR - http://www.scopus.com/inward/record.url?scp=85006162939&partnerID=8YFLogxK
U2 - 10.1155/2016/5392954
DO - 10.1155/2016/5392954
M3 - Journal article
AN - SCOPUS:85006162939
SN - 1741-427X
VL - 2016
JO - Evidence-based Complementary and Alternative Medicine
JF - Evidence-based Complementary and Alternative Medicine
M1 - 5392954
ER -
