TY - JOUR
T1 - Centipeda minima
T2 - An update on its phytochemistry, pharmacology and safety
AU - Tan, Jincheng
AU - Qiao, Zhiping
AU - Meng, Mingjing
AU - Zhang, Fan
AU - Kwan, Hiu Yee
AU - Zhong, Keying
AU - Yang, Chunfang
AU - Wang, Yechun
AU - Zhang, Mi
AU - Liu, Zhongqiu
AU - Su, Tao
N1 - Funding Information:
This work was supported by the Characteristic innovation projects of universities in Guangdong Province (2020KTSCX030), open project of State Key Laboratory of Quality Research in Chinese Medicine (Macau University of Science and Technology, SKL-QRCM(MUST)-2020-2022, 2R2103), Administration of Traditional Chinese Medicine of Guangdong Province (20222042), Guangdong Basic and Applied Basic Research Foundation (2020B1515130005), Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research(2020B1212030006), HKBU Initiation Grant for Faculty Niche Research Areas (RC-FNRA-IG/20–21/SCI/03), Innovation & Technology Commission (PRP/015/19FX), Free Exploration Basic Research Project in Shenzhen Virtual University Park (2021Szvup131) and Natural Science Foundation of Guangdong Province (2021A1515010655 and 2018A0303130122).
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/6/28
Y1 - 2022/6/28
N2 - Ethnopharmacological relevance: Centipeda minima (CM), the dried whole plant of Centipeda minima (L.) A. Braun and Aschers, has been used as a traditional Chinese medicinal herb for thousands of years for the treatments of rhinitis, sinusitis, cough and asthmatic diseases. This review aimed to evaluate the therapeutic potential of CM by summarizing its phytochemistry, pharmacology, clinical application and safety. Methods: This review summarizes the published studies on CM in the Chinese Pharmacopoeia and literature databases including PubMed, Web of Science, Baidu Scholar, Wiley and China Knowledge Resource Integrated Database (CNKI), as well as the research articles on the phytochemistry, pharmacology, clinical application and safety of CM. Results: A total of 191 compounds have been isolated and identified from CM, including terpenes, flavonoids, sterols, phenols, organic acids and volatile oils. In addition, the pharmacological effects of CM, such as anti-cancer, anti-inflammatory and anti-bacterial activities, have also been evaluated by both in vitro and in vivo studies. The signaling pathways and mechanisms of action underlying the anti-cancer effects of CM have been revealed. Clinical applications of CM mainly include rhinitis and sinusitis, gynecological inflammation, cough, as well as asthma. Conclusion: CM is a medicinal herb that possesses many therapeutic effects. Cutting-edge technology and system biology could provide us a more comprehensive understanding of the therapeutic effects, constituting components and toxicity of CM, which are the prerequisites for its translation into therapeutics for various disease treatments.
AB - Ethnopharmacological relevance: Centipeda minima (CM), the dried whole plant of Centipeda minima (L.) A. Braun and Aschers, has been used as a traditional Chinese medicinal herb for thousands of years for the treatments of rhinitis, sinusitis, cough and asthmatic diseases. This review aimed to evaluate the therapeutic potential of CM by summarizing its phytochemistry, pharmacology, clinical application and safety. Methods: This review summarizes the published studies on CM in the Chinese Pharmacopoeia and literature databases including PubMed, Web of Science, Baidu Scholar, Wiley and China Knowledge Resource Integrated Database (CNKI), as well as the research articles on the phytochemistry, pharmacology, clinical application and safety of CM. Results: A total of 191 compounds have been isolated and identified from CM, including terpenes, flavonoids, sterols, phenols, organic acids and volatile oils. In addition, the pharmacological effects of CM, such as anti-cancer, anti-inflammatory and anti-bacterial activities, have also been evaluated by both in vitro and in vivo studies. The signaling pathways and mechanisms of action underlying the anti-cancer effects of CM have been revealed. Clinical applications of CM mainly include rhinitis and sinusitis, gynecological inflammation, cough, as well as asthma. Conclusion: CM is a medicinal herb that possesses many therapeutic effects. Cutting-edge technology and system biology could provide us a more comprehensive understanding of the therapeutic effects, constituting components and toxicity of CM, which are the prerequisites for its translation into therapeutics for various disease treatments.
KW - Centipeda minima
KW - Clinical application
KW - Folk herb
KW - Pharmacology
KW - Phytochemistry
KW - Safety
UR - http://www.scopus.com/inward/record.url?scp=85127054267&partnerID=8YFLogxK
U2 - 10.1016/j.jep.2022.115027
DO - 10.1016/j.jep.2022.115027
M3 - Journal article
C2 - 35091011
AN - SCOPUS:85127054267
SN - 0378-8741
VL - 292
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
M1 - 115027
ER -
