Ceftriaxone ameliorates motor deficits and protects dopaminergic neurons in 6-hydroxydopamine-lesioned rats

T. C.H. Leung, C. N.P. Lui, L. W. Chen, W. H. Yung, Y. S. Chan, Kin Lam YUNG*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

64 Citations (Scopus)


Parkinson's disease is caused by the degeneration of dopaminergic neurons in substantia nigra. There is no current promising treatment for neuroprotection of dopaminergic neurons. Ceftriaxone is a beta-lactam antibiotic and has been reported to offer neuroprotective effects (Rothstein, J.-D., Patel, S., Regan, M.-R., Haenggeli, C., Huang, Y.-H., Bergles, D.-E., Jin, L., Dykes, H.-M., Vidensky, S., Chung, D.-S., Toan, S.-V., Bruijn, L.-I., Su, Z.-Z., Gupta, P., and Fisher, P.-B. (2005) Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression Nature433, 73-77). In the present study, efficacy of ceftriaxone in neuroprotection of dopaminergic neurons and amelioration of motor deficits in a rat model of Parkinson's disease were investigated. Ceftriaxone was administrated in 6-hydroxydopamine-lesioned rats. Using behavioral tests, grip strength and numbers of apomorphine-induced contralateral rotation were declined in the ceftriaxone-treated group. More importantly, cell death of dopaminergic neurons was found to decrease. In addition, both the protein expression and immunoreactivity for GLT-1 were up-regulated. The present results strongly indicate that ceftriaxone is a potential agent in the treatment of Parkinson's disease.

Original languageEnglish
Pages (from-to)22-30
Number of pages9
JournalACS Chemical Neuroscience
Issue number1
Early online date4 Nov 2011
Publication statusPublished - 18 Jan 2012

Scopus Subject Areas

  • Biochemistry
  • Physiology
  • Cognitive Neuroscience
  • Cell Biology

User-Defined Keywords

  • Animal model of Parkinson's disease
  • antibiotic
  • basal ganglia
  • ceftriaxone
  • degeneration of dopaminergic neurons
  • glutamate transporter
  • glutamate transporter subtype 1


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