Catalyst-free aza-Michael addition of azole to β,γ-unsaturated- α-keto ester: An efficient access to C-N bond formation

Jun WANG, Peng Fei Li*, Sau Hing Chan, Albert S.C. Chan, Fuk Yee Kwong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

An efficient aza-Michael addition of azoles to β,γ-unsaturated- α-keto esters under room temperature conditions has been developed. In this conjugate addition, no additional catalyst is employed. Azole reacts with β,γ-unsaturated-α-keto ester smoothly to afford new C-N bond adducts in good to excellent yields (up to 96%).

Original languageEnglish
Pages (from-to)2887-2889
Number of pages3
JournalTetrahedron Letters
Volume53
Issue number23
DOIs
Publication statusPublished - 6 Jun 2012

Scopus Subject Areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

User-Defined Keywords

  • Amination
  • Azole
  • Michael addition
  • Nitroalkene
  • Nitroolefin

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