Abstract
An efficient aza-Michael addition of azoles to β,γ-unsaturated- α-keto esters under room temperature conditions has been developed. In this conjugate addition, no additional catalyst is employed. Azole reacts with β,γ-unsaturated-α-keto ester smoothly to afford new C-N bond adducts in good to excellent yields (up to 96%).
Original language | English |
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Pages (from-to) | 2887-2889 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 53 |
Issue number | 23 |
DOIs | |
Publication status | Published - 6 Jun 2012 |
Scopus Subject Areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
User-Defined Keywords
- Amination
- Azole
- Michael addition
- Nitroalkene
- Nitroolefin