TY - GEN
T1 - CASP3, TP53, and MYC Targeted by Triptolide towards Ovary Induce Female Reproductive Toxicity
AU - Zheng, Guang
AU - Yan, Xue
AU - Yang, Yun
AU - Zhang, He
AU - Guo, Hongtao
AU - Zhan, Junping
AU - He, Xiaojuan
N1 - Publisher Copyright:
© 2016 IEEE.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/12/16
Y1 - 2016/12/16
N2 - Triptolide is an important active compound derived from Chinese herbal medicine Tripterygium wilfordii Hook f. Despite its positive therapeutic effects, the female reproductive toxicity is still blocking its clinical application with its toxicity mechanism is still obscure. In order to tackle the mechanism of female reproductive toxicity, one intuitive approach is to explore the biological molecule network involving targeted proteins and associated ovary expressed proteins. In this study, triptolide's target proteins and their biological functions were analyzed first. Then, focused on the enriched process of negative regulation of cell cycle, targeted proteins, together with proteins expressed in ovary which are contributed in negative regulation of cell cycle were extracted so as to form the female reproductive toxicity molecule network. Finally, three targeted proteins of CASP3, TP53, and MYC were highlighted as the leading causation of female reproductive toxicity. Further analysis indicated that these 3 target proteins can further regulate 21 ovary expressed proteins which also participate in associated processes. This study provides specified molecule level mechanism the female reproductive toxicity of triptolide which can be used to prevent toxicity while keeping its therapeutic effects.
AB - Triptolide is an important active compound derived from Chinese herbal medicine Tripterygium wilfordii Hook f. Despite its positive therapeutic effects, the female reproductive toxicity is still blocking its clinical application with its toxicity mechanism is still obscure. In order to tackle the mechanism of female reproductive toxicity, one intuitive approach is to explore the biological molecule network involving targeted proteins and associated ovary expressed proteins. In this study, triptolide's target proteins and their biological functions were analyzed first. Then, focused on the enriched process of negative regulation of cell cycle, targeted proteins, together with proteins expressed in ovary which are contributed in negative regulation of cell cycle were extracted so as to form the female reproductive toxicity molecule network. Finally, three targeted proteins of CASP3, TP53, and MYC were highlighted as the leading causation of female reproductive toxicity. Further analysis indicated that these 3 target proteins can further regulate 21 ovary expressed proteins which also participate in associated processes. This study provides specified molecule level mechanism the female reproductive toxicity of triptolide which can be used to prevent toxicity while keeping its therapeutic effects.
KW - Cell cycle
KW - Female reproductive toxicity
KW - Ovary
KW - Protein-protein interaction
KW - Target protein
KW - Triptolide
UR - http://www.scopus.com/inward/record.url?scp=85011031882&partnerID=8YFLogxK
U2 - 10.1109/BIBE.2016.11
DO - 10.1109/BIBE.2016.11
M3 - Conference proceeding
AN - SCOPUS:85011031882
T3 - Proceedings - 2016 IEEE 16th International Conference on Bioinformatics and Bioengineering, BIBE 2016
SP - 1
EP - 6
BT - Proceedings - 2016 IEEE 16th International Conference on Bioinformatics and Bioengineering, BIBE 2016
PB - IEEE
T2 - 16th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2016
Y2 - 31 October 2016 through 2 November 2016
ER -