CASP3, TP53, and MYC Targeted by Triptolide towards Ovary Induce Female Reproductive Toxicity

Guang Zheng, Xue Yan, Yun Yang, He Zhang, Hongtao Guo, Junping Zhan, Xiaojuan He

Research output: Chapter in book/report/conference proceedingConference contributionpeer-review

Abstract

Triptolide is an important active compound derived from Chinese herbal medicine Tripterygium wilfordii Hook f. Despite its positive therapeutic effects, the female reproductive toxicity is still blocking its clinical application with its toxicity mechanism is still obscure. In order to tackle the mechanism of female reproductive toxicity, one intuitive approach is to explore the biological molecule network involving targeted proteins and associated ovary expressed proteins. In this study, triptolide's target proteins and their biological functions were analyzed first. Then, focused on the enriched process of negative regulation of cell cycle, targeted proteins, together with proteins expressed in ovary which are contributed in negative regulation of cell cycle were extracted so as to form the female reproductive toxicity molecule network. Finally, three targeted proteins of CASP3, TP53, and MYC were highlighted as the leading causation of female reproductive toxicity. Further analysis indicated that these 3 target proteins can further regulate 21 ovary expressed proteins which also participate in associated processes. This study provides specified molecule level mechanism the female reproductive toxicity of triptolide which can be used to prevent toxicity while keeping its therapeutic effects.

Original languageEnglish
Title of host publicationProceedings - 2016 IEEE 16th International Conference on Bioinformatics and Bioengineering, BIBE 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1-6
Number of pages6
ISBN (Electronic)9781509038336
DOIs
Publication statusPublished - 16 Dec 2016
Event16th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2016 - Taichung, Taiwan, Province of China
Duration: 31 Oct 20162 Nov 2016

Publication series

NameProceedings - 2016 IEEE 16th International Conference on Bioinformatics and Bioengineering, BIBE 2016

Conference

Conference16th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2016
Country/TerritoryTaiwan, Province of China
CityTaichung
Period31/10/162/11/16

Scopus Subject Areas

  • Biotechnology
  • Genetics
  • Bioengineering
  • Biomedical Engineering
  • Health Informatics

User-Defined Keywords

  • Cell cycle
  • Female reproductive toxicity
  • Ovary
  • Protein-protein interaction
  • Target protein
  • Triptolide

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