Cardenolides from Saussurea stella with cytotoxicity toward cancer cells

Three new cardenolides, 3-O-β-D-fucopyranosylstrophanthidin (1), 3-O-β-D-quinovopyranosylperiplogenin (2), and 3-O-β-D-glucopyranosyl- (1→4)-α-L-rhamnopyranosylcannogenin (3), together with seven known cardenolides (4-10), were isolated from a cytotoxic ethanol extract of the whole dried plants of Saussurea Stella. The structures of these compounds were established by spectroscopic and chemical methods. When the cytotoxicity of compounds 2-10 toward Bel-7402 human hepatoma cells and BGC-823 human gastric cancer cells was evaluated, all compounds showed IC₅₀ values of <1 μM for both cell lines. This is the first report of cardenolides occurring in a species of the family Asteraceae.