Cardenolides from Saussurea stella with cytotoxicity toward cancer cells

Tian Min Wang, Toshinari Hojo, Fu Xiang Ran, Ru Feng Wang, Rui Qing Wang, Hubiao CHEN*, Jing Rong Cui, Ming Ying Shang, Shao Qing Cai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Three new cardenolides, 3-O-β-D-fucopyranosylstrophanthidin (1), 3-O-β-D-quinovopyranosylperiplogenin (2), and 3-O-β-D-glucopyranosyl- (1→4)-α-L-rhamnopyranosylcannogenin (3), together with seven known cardenolides (4-10), were isolated from a cytotoxic ethanol extract of the whole dried plants of Saussurea Stella. The structures of these compounds were established by spectroscopic and chemical methods. When the cytotoxicity of compounds 2-10 toward Bel-7402 human hepatoma cells and BGC-823 human gastric cancer cells was evaluated, all compounds showed IC50 values of <1 μM for both cell lines. This is the first report of cardenolides occurring in a species of the family Asteraceae.

Original languageEnglish
Pages (from-to)1429-1433
Number of pages5
JournalJournal of Natural Products
Volume70
Issue number9
DOIs
Publication statusPublished - Sep 2007

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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