Cardenolides from Saussurea stella with cytotoxicity toward cancer cells

Tian Min Wang; Toshinari Hojo; Fu Xiang Ran; Ru Feng Wang; Rui Qing Wang; Hubiao CHEN; Jing Rong Cui; Ming Ying Shang; Shao Qing Cai

doi:10.1021/np070150o

Cardenolides from Saussurea stella with cytotoxicity toward cancer cells

Tian Min Wang, Toshinari Hojo, Fu Xiang Ran, Ru Feng Wang, Rui Qing Wang, Hubiao CHEN^*, Jing Rong Cui, Ming Ying Shang, Shao Qing Cai

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Journal article › peer-review

33 Citations (Scopus)

Abstract

Three new cardenolides, 3-O-β-D-fucopyranosylstrophanthidin (1), 3-O-β-D-quinovopyranosylperiplogenin (2), and 3-O-β-D-glucopyranosyl- (1→4)-α-L-rhamnopyranosylcannogenin (3), together with seven known cardenolides (4-10), were isolated from a cytotoxic ethanol extract of the whole dried plants of Saussurea Stella. The structures of these compounds were established by spectroscopic and chemical methods. When the cytotoxicity of compounds 2-10 toward Bel-7402 human hepatoma cells and BGC-823 human gastric cancer cells was evaluated, all compounds showed IC₅₀ values of <1 μM for both cell lines. This is the first report of cardenolides occurring in a species of the family Asteraceae.

Original language	English
Pages (from-to)	1429-1433
Number of pages	5
Journal	Journal of Natural Products
Volume	70
Issue number	9
DOIs	https://doi.org/10.1021/np070150o
Publication status	Published - Sept 2007

Scopus Subject Areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/np070150o

Cite this

@article{fa1bde135d8940fc809dcf2250507dcf,

title = "Cardenolides from Saussurea stella with cytotoxicity toward cancer cells",

abstract = "Three new cardenolides, 3-O-β-D-fucopyranosylstrophanthidin (1), 3-O-β-D-quinovopyranosylperiplogenin (2), and 3-O-β-D-glucopyranosyl- (1→4)-α-L-rhamnopyranosylcannogenin (3), together with seven known cardenolides (4-10), were isolated from a cytotoxic ethanol extract of the whole dried plants of Saussurea Stella. The structures of these compounds were established by spectroscopic and chemical methods. When the cytotoxicity of compounds 2-10 toward Bel-7402 human hepatoma cells and BGC-823 human gastric cancer cells was evaluated, all compounds showed IC50 values of <1 μM for both cell lines. This is the first report of cardenolides occurring in a species of the family Asteraceae.",

author = "Wang, {Tian Min} and Toshinari Hojo and Ran, {Fu Xiang} and Wang, {Ru Feng} and Wang, {Rui Qing} and Hubiao CHEN and Cui, {Jing Rong} and Shang, {Ming Ying} and Cai, {Shao Qing}",

note = "This work was supported financially by the Program for Changjiang Scholar and Innovative Team in University (grant number: 985-2-063-112) of the Ministry of Education of China and the second 985 Project of Peking University. ",

year = "2007",

month = sep,

doi = "10.1021/np070150o",

language = "English",

volume = "70",

pages = "1429--1433",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "9",

}

TY - JOUR

T1 - Cardenolides from Saussurea stella with cytotoxicity toward cancer cells

AU - Wang, Tian Min

AU - Hojo, Toshinari

AU - Ran, Fu Xiang

AU - Wang, Ru Feng

AU - Wang, Rui Qing

AU - CHEN, Hubiao

AU - Cui, Jing Rong

AU - Shang, Ming Ying

AU - Cai, Shao Qing

N1 - This work was supported financially by the Program for Changjiang Scholar and Innovative Team in University (grant number: 985-2-063-112) of the Ministry of Education of China and the second 985 Project of Peking University.

PY - 2007/9

Y1 - 2007/9

N2 - Three new cardenolides, 3-O-β-D-fucopyranosylstrophanthidin (1), 3-O-β-D-quinovopyranosylperiplogenin (2), and 3-O-β-D-glucopyranosyl- (1→4)-α-L-rhamnopyranosylcannogenin (3), together with seven known cardenolides (4-10), were isolated from a cytotoxic ethanol extract of the whole dried plants of Saussurea Stella. The structures of these compounds were established by spectroscopic and chemical methods. When the cytotoxicity of compounds 2-10 toward Bel-7402 human hepatoma cells and BGC-823 human gastric cancer cells was evaluated, all compounds showed IC50 values of <1 μM for both cell lines. This is the first report of cardenolides occurring in a species of the family Asteraceae.

AB - Three new cardenolides, 3-O-β-D-fucopyranosylstrophanthidin (1), 3-O-β-D-quinovopyranosylperiplogenin (2), and 3-O-β-D-glucopyranosyl- (1→4)-α-L-rhamnopyranosylcannogenin (3), together with seven known cardenolides (4-10), were isolated from a cytotoxic ethanol extract of the whole dried plants of Saussurea Stella. The structures of these compounds were established by spectroscopic and chemical methods. When the cytotoxicity of compounds 2-10 toward Bel-7402 human hepatoma cells and BGC-823 human gastric cancer cells was evaluated, all compounds showed IC50 values of <1 μM for both cell lines. This is the first report of cardenolides occurring in a species of the family Asteraceae.

UR - http://www.scopus.com/inward/record.url?scp=35348859494&partnerID=8YFLogxK

U2 - 10.1021/np070150o

DO - 10.1021/np070150o

M3 - Journal article

C2 - 17844995

AN - SCOPUS:35348859494

SN - 0163-3864

VL - 70

SP - 1429

EP - 1433

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -

Cardenolides from Saussurea stella with cytotoxicity toward cancer cells

Abstract

Scopus Subject Areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this