Carbazole-based two-photon fluorescent probe for selective imaging of mitochondrial hydrogen peroxide in living cells and tissues

Kai Zhang; Wei Wu; Yinhui Li; Mingtai Sun; Huan Yu; Ricky M S Wong

doi:10.1039/c6ra21260c

Carbazole-based two-photon fluorescent probe for selective imaging of mitochondrial hydrogen peroxide in living cells and tissues

Kai Zhang
, Wei Wu
, Yinhui Li^*
, Mingtai Sun
, Huan Yu^*
, Ricky M S Wong^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

19 Citations (Scopus)

Abstract

This paper reported a two-photon fluorescent probe for mitochondrial H₂O₂ detection and imaging based on the incorporation of a sensing boronate ester and an organelle-targeting triphenylphosphonium moiety onto the carbazole fluorophore. The probe exhibits a fast “turn on” response, good selectivity toward H₂O₂ and high specificity for mitochondria.

Original language	English
Pages (from-to)	115298-115302
Number of pages	5
Journal	RSC Advances
Volume	6
Issue number	116
DOIs	https://doi.org/10.1039/c6ra21260c
Publication status	Published - 24 Dec 2016

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10.1039/c6ra21260c

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@article{00d188bd9fa1465db81098902a88f8bd,

title = "Carbazole-based two-photon fluorescent probe for selective imaging of mitochondrial hydrogen peroxide in living cells and tissues",

abstract = "This paper reported a two-photon fluorescent probe for mitochondrial H2O2 detection and imaging based on the incorporation of a sensing boronate ester and an organelle-targeting triphenylphosphonium moiety onto the carbazole fluorophore. The probe exhibits a fast “turn on” response, good selectivity toward H2O2 and high specificity for mitochondria.",

author = "Kai Zhang and Wei Wu and Yinhui Li and Mingtai Sun and Huan Yu and Wong, \{Ricky M S\}",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (21305036, 21507135), Hunan Provincial Natural Science Foundation of China (2015JJ3035), China Postdoctoral Science Foundation funded project (2015M580685) and Anhui Province Natural Science Foundation of China (1608085MB30).",

year = "2016",

month = dec,

day = "24",

doi = "10.1039/c6ra21260c",

language = "English",

volume = "6",

pages = "115298--115302",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

number = "116",

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TY - JOUR

T1 - Carbazole-based two-photon fluorescent probe for selective imaging of mitochondrial hydrogen peroxide in living cells and tissues

AU - Zhang, Kai

AU - Wu, Wei

AU - Li, Yinhui

AU - Sun, Mingtai

AU - Yu, Huan

AU - Wong, Ricky M S

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (21305036, 21507135), Hunan Provincial Natural Science Foundation of China (2015JJ3035), China Postdoctoral Science Foundation funded project (2015M580685) and Anhui Province Natural Science Foundation of China (1608085MB30).

PY - 2016/12/24

Y1 - 2016/12/24

N2 - This paper reported a two-photon fluorescent probe for mitochondrial H2O2 detection and imaging based on the incorporation of a sensing boronate ester and an organelle-targeting triphenylphosphonium moiety onto the carbazole fluorophore. The probe exhibits a fast “turn on” response, good selectivity toward H2O2 and high specificity for mitochondria.

AB - This paper reported a two-photon fluorescent probe for mitochondrial H2O2 detection and imaging based on the incorporation of a sensing boronate ester and an organelle-targeting triphenylphosphonium moiety onto the carbazole fluorophore. The probe exhibits a fast “turn on” response, good selectivity toward H2O2 and high specificity for mitochondria.

UR - https://www.scopus.com/pages/publications/85006409740

U2 - 10.1039/c6ra21260c

DO - 10.1039/c6ra21260c

M3 - Journal article

AN - SCOPUS:85006409740

SN - 2046-2069

VL - 6

SP - 115298

EP - 115302

JO - RSC Advances

JF - RSC Advances

IS - 116

ER -

Carbazole-based two-photon fluorescent probe for selective imaging of mitochondrial hydrogen peroxide in living cells and tissues

Abstract

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