Calcium signaling in Alzheimer's disease & therapies

Chun Kit Benjamin TONG, Aston Jiaxi Wu, Min LI, King-Ho CHEUNG*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

52 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is the most common type of dementia and is characterized by the accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Much attention has been given to develop AD treatments based on the amyloid cascade hypothesis; however, none of these drugs had good efficacy at improving cognitive functions in AD patients suggesting that Aβ might not be the disease origin. Thus, there are urgent needs for the development of new therapies that target on the proximal cause of AD. Cellular calcium (Ca 2+ ) signals regulate important facets of neuronal physiology. An increasing body of evidence suggests that age-related dysregulation of neuronal Ca 2+ homeostasis may play a proximal role in the pathogenesis of AD as disrupted Ca 2+ could induce synaptic deficits and promote the accumulation of Aβ plaques and neurofibrillary tangles. Given that Ca 2+ disruption is ubiquitously involved in all AD pathologies, it is likely that using chemical agents or small molecules specific to Ca 2+ channels or handling proteins on the plasma membrane and membranes of intracellular organelles to correct neuronal Ca 2+ dysregulation could open up a new approach to AD prevention and treatment. This review summarizes current knowledge on the molecular mechanisms linking Ca 2+ dysregulation with AD pathologies and discusses the possibility of correcting neuronal Ca 2+ disruption as a therapeutic approach for AD.

Original languageEnglish
Pages (from-to)1745-1760
Number of pages16
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1865
Issue number11
DOIs
Publication statusPublished - Nov 2018

Scopus Subject Areas

  • Molecular Biology
  • Cell Biology

User-Defined Keywords

  • Alzheimer's disease
  • Ca channels
  • Calcium
  • Channelopathy
  • Therapy

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