@article{5ad9efdab9a14beea086ec7ee2e74ca7,
title = "Bruguiesulfurol, a new sulfur compound from Bruguiera gymnorrhiza",
abstract = "A new cyclic 4-hydroxy-dithiosulfonato, bruguiesulfurol (1), as well as two known 4-hydroxydithiolane 1-oxides, brugierol (2) and isobrugierol (3) were isolated from the flowers of Bruguiera gymnorrhiza. With stably-transfected HepG2 cells, the three isolates activated antioxidant response element (ARE) luciferase activation with (EC50) values of 56.7, 3.7 and 1.8 μM, respectively. Compounds 2 and 3 also inhibited phorbol ester-induced NF-κB (nuclear factor-κB) luciferase activity with IC50 values of 85.0 and 14.5 μM, respectively. In addition, compound 2 inhibited enzyme cyclooxygenase-2 (COX-2) activity with an IC50 value of 6.1 μM. The structures of these isolates were determined by spectral data, and that of compound 1 was confirmed by X-ray crystallographic analysis.",
keywords = "ARE induction, Bruguiera gymnorrhiza, Bruguiesulfurol, COX-1, COX-2, Dithiosulfonate, NF-κB inhibition, NMR, Rhizophoraceae, X-ray",
author = "Sudarat Homhual and Hongjie ZHANG and Nuntavan Bunyapraphatsara and Kondratyuk, \{Tamara P.\} and Santarsiero, \{Bernard D.\} and Mesecar, \{Andrew D.\} and Angkana Herunsalee and Wongsatit Chaukul and Pezzuto, \{John M.\} and Fong, \{Harry H.S.\}",
note = "This study was supported in part by program project P01 CA48112 funded by the National Cancer Institute, NIH, Bethesda, MD, and in part by the Thailand Research Fund through the Royal Golden Jubilee Ph.D. program (Grant No. PHD/0191/2545) awarded to SH and NB. The authors are grateful to the NMR group of the College of Pharmacy, University of Illinois at Chicago for access to NMR instruments required for this study. The authors are also grateful to the Resource Research Center, University of Illinois at Chicago for the acquisition of MS data, and for funding from the National Institutes of Health, NCRR, for purchase of the X-ray diffractometer.",
year = "2006",
month = feb,
doi = "10.1055/s-2005-873171",
language = "English",
volume = "72",
pages = "255--260",
journal = "Planta Medica",
issn = "0032-0943",
publisher = "Georg Thieme Verlag",
number = "3",
}