@article{26eb85df6c144a50a2f2c86888471a20,
title = "BRI1/BAK1, a receptor kinase pair mediating brassinosteroid signaling",
abstract = "The Arabidopsis BAK1 (BRI1 Associated receptor Kinase 1) was identified by a yeast two-hybrid screen as a specific interactor for BRI1, a critical component of a membrane brassinosteroid (BR) receptor. In yeast, BAK1/BRI1 interaction activates their kinase activities through transphosphorylation. BAK1 and BRI1 share similar gene expression and subcellular localization patterns and physically associate with each other in plants. Overexpression of the BAK1 gene leads to a phenotype reminiscent of BRI1-overexpression transgenic plants and rescues a weak bri1 mutant. In contrast, a bak1 knockout mutation gives rise to a weak bri1-like phenotype and enhances a weak bri1 mutation. We propose that BAK1 and BRI1 function together to mediate plant steroid signaling.",
author = "Nam, {Kyoung Hee} and Jianming Li",
note = "We thank S. Clark, J. Schiefelbein, and two anonymous reviewers for critical comments on the manuscript; J. Walker for proofreading the final version of the manuscript; members of the Li lab for helpful discussions; J. Chory for support of the early phase of the yeast two-hybrid work and providing anti-BRI1 antibodies; and C. Fankhauser for the pAS2-PHYA-C plasmid. We are grateful to the Arabidopsis Biological Resource Center (Ohio State University, Columbus, OH) for Arabidopsis seeds and DNA clones, and the Arabidopsis Gene Knockout Facility (University of Wisconsin, Madison, WI) for screening the bak1 mutant. This work was supported in part by a University of Michigan startup fund, a University of Michigan Rackham Faculty Research Award, and a NIH grant (GM60519) to J.L. Publisher Copyright: {\textcopyright} 2002 Cell Press. All rights reserved. ",
year = "2002",
month = jul,
day = "26",
doi = "10.1016/S0092-8674(02)00814-0",
language = "English",
volume = "110",
pages = "203--212",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier B.V.",
number = "2",
}