Bone marrow stromal cell-derived growth inhibitor serves as a stress sensor to induce autophagy

Jianbin Zhang, Liming Wang, Jian Xu, Yancheng Tang, Bo Huang, Zhifeng Chen, Ting Zhang, Han Ming Shen, Yihua Wu*, Dajing Xia

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Autophagy is an evolutionarily conserved stress response that promotes the lysosomal degradation of intracellular components. The bone marrow stromal cell-derived growth inhibitor (BDGI) functions as a stress sensor which is upregulated by oxidative stress and DNA damage. However, the role of BDGI in autophagic response to certain stresses remains unknown. Here, our results demonstrate that BDGI defines the impact of autophagy induction under stresses. Overexpression of BDGI promotes, while knockdown of BDGI impairs, autophagy. Mechanistically, BDGI localizes to the nucleus and interacts with the transcription factor transcription factor EB to increase the expression of multiple autophagy- and lysosome-related genes. In addition, BDGI regulates autophagy in a p53-dependent manner. Furthermore, BDGI-induced autophagy enables cell survival under stress conditions. Taken together, our study demonstrates that BDGI is a stress sensor that positively regulates autophagy.

Original languageEnglish
Pages (from-to)1248-1260
Number of pages13
JournalFEBS Letters
Volume594
Issue number8
DOIs
Publication statusPublished - 1 Apr 2020

Scopus Subject Areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

User-Defined Keywords

  • autophagy
  • BDGI
  • cell death
  • p53
  • TFEB

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