TY - JOUR
T1 - Bone-derived exosomes
AU - LIU, Jin
AU - LI, Defang
AU - Wu, Xiaohao
AU - Dang, Lei
AU - LYU, Aiping
AU - ZHANG, Ge
N1 - Funding Information:
This work was supported by the Ministry of Science and Technology of China ( 2013ZX09301307 to A.L.), the Hong Kong General Research Fund ( HKBU479111 to G.Z., HKBU478312 to G.Z., HKBU262913 to G.Z., HKBU12102914 to G.Z., HKBU261113 to A.L), the Natural Science Foundation Council of China ( 81272045 to G.Z.), the Research Grants Council and Natural Science Foundation Council of China ( N_HKBU435/12 to G.Z.), the Croucher Foundation ( Gnt#CAS14BU/CAS14201 to G.Z.), the Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong Baptist University ( RC-IRMS/12-13/02 to A.L. and RC-IRMS/13-14/02 to G.Z.), the Hong Kong Baptist University Strategic Development Fund ( SDF13-1209-P01 to A.L.), the Hong Kong Research Grants Council Early Career Scheme ( 489213 to G.Z.), the Inter-institutional Collaborative Research Scheme of Hong Kong Baptist University ( RC-ICRS/14-15/01 to G.Z.), the Faculty Research Grant of Hong Kong Baptist University ( FRG1/13-14/024 to G.Z., FRG2/13-14/006 to G.Z. and FRG2/14-15/010 to G.Z.).
PY - 2017/6
Y1 - 2017/6
N2 - Exosomes are endosomal-derived vesicles secreted by a wide range of cell types for transporting functional proteins, microRNAs (miRNAs) and messenger RNAs (mRNA) from their parental cells to affect the recipient cells. Emerging evidence indicates that exosomes also play an important role in the intercellular communication among the bone cells, that is, osteoblasts, osteoclasts and bone marrow stromal cells, within bone microenvironment. Here, we reviewed the local and systemic effects of bone-derived exosomes, and discussed the potential of exosomes as targeted delivery systems for molecular therapy in skeletal disorders.
AB - Exosomes are endosomal-derived vesicles secreted by a wide range of cell types for transporting functional proteins, microRNAs (miRNAs) and messenger RNAs (mRNA) from their parental cells to affect the recipient cells. Emerging evidence indicates that exosomes also play an important role in the intercellular communication among the bone cells, that is, osteoblasts, osteoclasts and bone marrow stromal cells, within bone microenvironment. Here, we reviewed the local and systemic effects of bone-derived exosomes, and discussed the potential of exosomes as targeted delivery systems for molecular therapy in skeletal disorders.
UR - http://www.scopus.com/inward/record.url?scp=85028702193&partnerID=8YFLogxK
U2 - 10.1016/j.coph.2017.08.008
DO - 10.1016/j.coph.2017.08.008
M3 - Review article
C2 - 28881252
AN - SCOPUS:85028702193
SN - 1471-4892
VL - 34
SP - 64
EP - 69
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
ER -