TY - JOUR
T1 - Blood pressure changes during pregnancy in relation to urinary paraben, triclosan and benzophenone concentrations
T2 - A repeated measures study
AU - Liu, Hongxiu
AU - Li, Jiufeng
AU - Xia, Wei
AU - Zhang, Bin
AU - Peng, Yang
AU - Li, Yuanyuan
AU - Zhou, Yanqiu
AU - Fang, Jing
AU - Zhao, Hongzhi
AU - Jiang, Yangqian
AU - Liu, Wenyu
AU - Sun, Xiaojie
AU - Hu, Cheng
AU - CAI, Zongwei
AU - Xu, Shunqing
N1 - Funding Information:
This work was supported by the National Key Research and Development Plan of China (grant nos. 2016YFC0206700 , 2016YFC0206203 ) and the National Natural Science Foundation of China (grant nos. 81372959 , 21437002 , 81402649 , 91643207 , and 21777010 ).
PY - 2019/1
Y1 - 2019/1
N2 - Previous studies have proven the endocrine-disrupting properties and health hazards of parabens, triclosan, and benzophenones, but their relationship with blood pressure during pregnancy remains unknown. Therefore, we investigated the associations of repeated measures of urinary parabens, triclosan, and benzophenones with blood pressure during pregnancy and evaluated whether the associations were modified by fetal sex. From a prospective birth cohort in Wuhan, China, we collected urine samples from 644 pregnant women in the first, second, and third trimesters between 2014 and 2015. Five parabens, triclosan, and three benzophenones were quantified in all urine samples. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured in each trimester after urine sampling. Mixed linear models were used to estimate the associations between urinary chemical levels and blood pressure during pregnancy among all pregnant women and subgroups stratified by fetal sex. In the women carrying male fetuses, urinary triclosan and selected benzophenone concentrations were associated with a slight change of SBP during pregnancy. In the women carrying female fetuses, no chemical was associated with SBP, while urinary concentration of triclosan was inversely associated with DBP, though the magnitude was small. Urinary paraben levels weren't associated with blood pressure during pregnancy. Our results suggest that triclosan and selected benzophenone exposure might be associated with blood pressure during pregnancy in a potential fetal sex-different manner. Replicated research studies in pregnant women with higher triclosan and benzophenone exposure levels are needed in the future.
AB - Previous studies have proven the endocrine-disrupting properties and health hazards of parabens, triclosan, and benzophenones, but their relationship with blood pressure during pregnancy remains unknown. Therefore, we investigated the associations of repeated measures of urinary parabens, triclosan, and benzophenones with blood pressure during pregnancy and evaluated whether the associations were modified by fetal sex. From a prospective birth cohort in Wuhan, China, we collected urine samples from 644 pregnant women in the first, second, and third trimesters between 2014 and 2015. Five parabens, triclosan, and three benzophenones were quantified in all urine samples. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured in each trimester after urine sampling. Mixed linear models were used to estimate the associations between urinary chemical levels and blood pressure during pregnancy among all pregnant women and subgroups stratified by fetal sex. In the women carrying male fetuses, urinary triclosan and selected benzophenone concentrations were associated with a slight change of SBP during pregnancy. In the women carrying female fetuses, no chemical was associated with SBP, while urinary concentration of triclosan was inversely associated with DBP, though the magnitude was small. Urinary paraben levels weren't associated with blood pressure during pregnancy. Our results suggest that triclosan and selected benzophenone exposure might be associated with blood pressure during pregnancy in a potential fetal sex-different manner. Replicated research studies in pregnant women with higher triclosan and benzophenone exposure levels are needed in the future.
UR - http://www.scopus.com/inward/record.url?scp=85057396019&partnerID=8YFLogxK
U2 - 10.1016/j.envint.2018.11.003
DO - 10.1016/j.envint.2018.11.003
M3 - Journal article
C2 - 30503318
AN - SCOPUS:85057396019
SN - 0160-4120
VL - 122
SP - 185
EP - 192
JO - Environment International
JF - Environment International
ER -