Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement

Chen Xie; Ho Fai Chau; Jing Xiang Zhang; Sheng Tong; Lijun Jiang; Wan Yiu Fok; Hong Lok Lung; Shuai Zha; Rui Zou; Ju Jiao; Chi Fai Ng; Ping'an Ma; Junhui Zhang; Jun Lin; Kwok Keung Shiu; Jean Claude G. Bünzli; Wai Kwok Wong; Nicholas J. Long; Ga Lai Law; Ka Leung Wong

doi:10.1002/adtp.201900068

Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement

Chen Xie
, Ho Fai Chau
, Jing Xiang Zhang
, Sheng Tong
, Lijun Jiang
, Wan Yiu Fok
, Hong Lok Lung
, Shuai Zha
, Rui Zou
, Ju Jiao
, Chi Fai Ng
, Ping'an Ma
, Junhui Zhang
, Jun Lin
, Kwok Keung Shiu
, Jean Claude G. Bünzli
, Wai Kwok Wong
, Nicholas J. Long^*
, Ga Lai Law^*
, Ka Leung Wong^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

24 Citations (Scopus)

Abstract

Acting as an extracellular matrix protein receptor, α_Vβ₃ integrin becomes an appealing target for photodynamic therapy of bladder cancer. Here, specific α_Vβ₃-integrin-targeting porphyrinato-gadolinium complexes (Gd-PEG-Rⁿ) are demonstrated as off-on theranostic agents, where Rⁿ are specific peptides. Among them, Gd-PEG-R³ shows both impressive phototherapeutic index and robust in vivo magnetic resonance imaging (MRI) signal enhancement. Significant selectivity of Gd-PEG-R³ is proven by its high α_Vβ₃ integrin binding affinity in positive bladder cancer cells. All these findings support Gd-PEG-R³ as a promising bi-functional medical agent with both MRI contrasting ability and photodynamic therapeutic potential for curing bladder cancer.

Original language	English
Article number	1900068
Number of pages	7
Journal	Advanced Therapeutics
Volume	2
Issue number	11
Early online date	16 Jun 2019
DOIs	https://doi.org/10.1002/adtp.201900068
Publication status	Published - Nov 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

bladder cancer
lanthanide
magnetic resonance imaging
photodynamic therapy
porphyrin

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10.1002/adtp.201900068

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Xie, C., Chau, H. F., Zhang, J. X., Tong, S., Jiang, L., Fok, W. Y., Lung, H. L., Zha, S., Zou, R., Jiao, J., Ng, C. F., Ma, P., Zhang, J., Lin, J., Shiu, K. K., Bünzli, J. C. G., Wong, W. K., Long, N. J., Law, G. L., & Wong, K. L. (2019). Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement. Advanced Therapeutics, 2(11), Article 1900068. https://doi.org/10.1002/adtp.201900068

@article{4ef1646f9d86401ab704ef499c115bd5,

title = "Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement",

abstract = "Acting as an extracellular matrix protein receptor, αVβ3 integrin becomes an appealing target for photodynamic therapy of bladder cancer. Here, specific αVβ3-integrin-targeting porphyrinato-gadolinium complexes (Gd-PEG-Rn) are demonstrated as off-on theranostic agents, where Rn are specific peptides. Among them, Gd-PEG-R3 shows both impressive phototherapeutic index and robust in vivo magnetic resonance imaging (MRI) signal enhancement. Significant selectivity of Gd-PEG-R3 is proven by its high αVβ3 integrin binding affinity in positive bladder cancer cells. All these findings support Gd-PEG-R3 as a promising bi-functional medical agent with both MRI contrasting ability and photodynamic therapeutic potential for curing bladder cancer.",

keywords = "bladder cancer, lanthanide, magnetic resonance imaging, photodynamic therapy, porphyrin",

author = "Chen Xie and Chau, \{Ho Fai\} and Zhang, \{Jing Xiang\} and Sheng Tong and Lijun Jiang and Fok, \{Wan Yiu\} and Lung, \{Hong Lok\} and Shuai Zha and Rui Zou and Ju Jiao and Ng, \{Chi Fai\} and Ping'an Ma and Junhui Zhang and Jun Lin and Shiu, \{Kwok Keung\} and B{\"u}nzli, \{Jean Claude G.\} and Wong, \{Wai Kwok\} and Long, \{Nicholas J.\} and Law, \{Ga Lai\} and Wong, \{Ka Leung\}",

note = "Funding Information: C.X. and H.-F.C. contributed equally to this work. This work was supported by grants from The Hong Kong Research Grant Council (HKBU12309516), the Hong Kong Baptist University (RC-ICRS/16-17/02-CHEM), CAS Croucher joint lab (CA18204), The Hong Kong Polytechnic University [Univeristy Research Facility for Chemical and Environmental Analysis (UCEA)]and The University Research Facility in Life Sciences (ULS), and The Hong Kong Research Grant Council PolyU 153013/17P and PolyU 153103/16P, also by the assistance from the Imperial College London. Publisher Copyright: {\textcopyright} 2019 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2019",

month = nov,

doi = "10.1002/adtp.201900068",

language = "English",

volume = "2",

journal = "Advanced Therapeutics",

issn = "2366-3987",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "11",

}

Xie, C, Chau, HF, Zhang, JX, Tong, S, Jiang, L, Fok, WY, Lung, HL, Zha, S, Zou, R, Jiao, J, Ng, CF, Ma, P, Zhang, J, Lin, J, Shiu, KK, Bünzli, JCG, Wong, WK, Long, NJ, Law, GL & Wong, KL 2019, 'Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement', Advanced Therapeutics, vol. 2, no. 11, 1900068. https://doi.org/10.1002/adtp.201900068

TY - JOUR

T1 - Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement

AU - Xie, Chen

AU - Chau, Ho Fai

AU - Zhang, Jing Xiang

AU - Tong, Sheng

AU - Jiang, Lijun

AU - Fok, Wan Yiu

AU - Lung, Hong Lok

AU - Zha, Shuai

AU - Zou, Rui

AU - Jiao, Ju

AU - Ng, Chi Fai

AU - Ma, Ping'an

AU - Zhang, Junhui

AU - Lin, Jun

AU - Shiu, Kwok Keung

AU - Bünzli, Jean Claude G.

AU - Wong, Wai Kwok

AU - Long, Nicholas J.

AU - Law, Ga Lai

AU - Wong, Ka Leung

N1 - Funding Information: C.X. and H.-F.C. contributed equally to this work. This work was supported by grants from The Hong Kong Research Grant Council (HKBU12309516), the Hong Kong Baptist University (RC-ICRS/16-17/02-CHEM), CAS Croucher joint lab (CA18204), The Hong Kong Polytechnic University [Univeristy Research Facility for Chemical and Environmental Analysis (UCEA)]and The University Research Facility in Life Sciences (ULS), and The Hong Kong Research Grant Council PolyU 153013/17P and PolyU 153103/16P, also by the assistance from the Imperial College London. Publisher Copyright: © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2019/11

Y1 - 2019/11

N2 - Acting as an extracellular matrix protein receptor, αVβ3 integrin becomes an appealing target for photodynamic therapy of bladder cancer. Here, specific αVβ3-integrin-targeting porphyrinato-gadolinium complexes (Gd-PEG-Rn) are demonstrated as off-on theranostic agents, where Rn are specific peptides. Among them, Gd-PEG-R3 shows both impressive phototherapeutic index and robust in vivo magnetic resonance imaging (MRI) signal enhancement. Significant selectivity of Gd-PEG-R3 is proven by its high αVβ3 integrin binding affinity in positive bladder cancer cells. All these findings support Gd-PEG-R3 as a promising bi-functional medical agent with both MRI contrasting ability and photodynamic therapeutic potential for curing bladder cancer.

AB - Acting as an extracellular matrix protein receptor, αVβ3 integrin becomes an appealing target for photodynamic therapy of bladder cancer. Here, specific αVβ3-integrin-targeting porphyrinato-gadolinium complexes (Gd-PEG-Rn) are demonstrated as off-on theranostic agents, where Rn are specific peptides. Among them, Gd-PEG-R3 shows both impressive phototherapeutic index and robust in vivo magnetic resonance imaging (MRI) signal enhancement. Significant selectivity of Gd-PEG-R3 is proven by its high αVβ3 integrin binding affinity in positive bladder cancer cells. All these findings support Gd-PEG-R3 as a promising bi-functional medical agent with both MRI contrasting ability and photodynamic therapeutic potential for curing bladder cancer.

KW - bladder cancer

KW - lanthanide

KW - magnetic resonance imaging

KW - photodynamic therapy

KW - porphyrin

UR - https://www.scopus.com/pages/publications/85080976482

U2 - 10.1002/adtp.201900068

DO - 10.1002/adtp.201900068

M3 - Journal article

AN - SCOPUS:85080976482

SN - 2366-3987

VL - 2

JO - Advanced Therapeutics

JF - Advanced Therapeutics

IS - 11

M1 - 1900068

ER -

Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement

Abstract

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