Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement

Chen Xie, Ho Fai Chau, Jing Xiang Zhang, Sheng Tong, Lijun Jiang, Wan Yiu Fok, Hong Lok Lung, Shuai Zha, Rui Zou, Ju Jiao, Chi Fai Ng, Ping'an Ma, Junhui Zhang, Jun Lin, Kwok Keung Shiu, Jean Claude G. Bünzli, Wai Kwok Wong, Nicholas J. Long*, Ga Lai Law*, Ka Leung Wong*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Acting as an extracellular matrix protein receptor, αVβ3 integrin becomes an appealing target for photodynamic therapy of bladder cancer. Here, specific αVβ3-integrin-targeting porphyrinato-gadolinium complexes (Gd-PEG-Rn) are demonstrated as off-on theranostic agents, where Rn are specific peptides. Among them, Gd-PEG-R3 shows both impressive phototherapeutic index and robust in vivo magnetic resonance imaging (MRI) signal enhancement. Significant selectivity of Gd-PEG-R3 is proven by its high αVβ3 integrin binding affinity in positive bladder cancer cells. All these findings support Gd-PEG-R3 as a promising bi-functional medical agent with both MRI contrasting ability and photodynamic therapeutic potential for curing bladder cancer.

Original languageEnglish
Article number1900068
Number of pages7
JournalAdvanced Therapeutics
Volume2
Issue number11
Early online date16 Jun 2019
DOIs
Publication statusPublished - Nov 2019

Scopus Subject Areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Pharmaceutical Science
  • Genetics(clinical)
  • Biochemistry, medical
  • Pharmacology (medical)

User-Defined Keywords

  • bladder cancer
  • lanthanide
  • magnetic resonance imaging
  • photodynamic therapy
  • porphyrin

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