@article{4ef1646f9d86401ab704ef499c115bd5,
title = "Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement",
abstract = "Acting as an extracellular matrix protein receptor, αVβ3 integrin becomes an appealing target for photodynamic therapy of bladder cancer. Here, specific αVβ3-integrin-targeting porphyrinato-gadolinium complexes (Gd-PEG-Rn) are demonstrated as off-on theranostic agents, where Rn are specific peptides. Among them, Gd-PEG-R3 shows both impressive phototherapeutic index and robust in vivo magnetic resonance imaging (MRI) signal enhancement. Significant selectivity of Gd-PEG-R3 is proven by its high αVβ3 integrin binding affinity in positive bladder cancer cells. All these findings support Gd-PEG-R3 as a promising bi-functional medical agent with both MRI contrasting ability and photodynamic therapeutic potential for curing bladder cancer.",
keywords = "bladder cancer, lanthanide, magnetic resonance imaging, photodynamic therapy, porphyrin",
author = "Chen Xie and Chau, {Ho Fai} and Zhang, {Jing Xiang} and Sheng Tong and Lijun Jiang and Fok, {Wan Yiu} and Lung, {Hong Lok} and Shuai Zha and Rui Zou and Ju Jiao and Ng, {Chi Fai} and Ping'an Ma and Junhui Zhang and Jun Lin and Shiu, {Kwok Keung} and B{\"u}nzli, {Jean Claude G.} and Wong, {Wai Kwok} and Long, {Nicholas J.} and Law, {Ga Lai} and Wong, {Ka Leung}",
note = "Funding Information: C.X. and H.-F.C. contributed equally to this work. This work was supported by grants from The Hong Kong Research Grant Council (HKBU12309516), the Hong Kong Baptist University (RC-ICRS/16-17/02-CHEM), CAS Croucher joint lab (CA18204), The Hong Kong Polytechnic University [Univeristy Research Facility for Chemical and Environmental Analysis (UCEA)]and The University Research Facility in Life Sciences (ULS), and The Hong Kong Research Grant Council PolyU 153013/17P and PolyU 153103/16P, also by the assistance from the Imperial College London. Publisher Copyright: {\textcopyright} 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2019",
month = nov,
doi = "10.1002/adtp.201900068",
language = "English",
volume = "2",
journal = "Advanced Therapeutics",
issn = "2366-3987",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "11",
}