Bisindigotin, a TCDD antagonist from the Chinese medicinal herb Isatis indigotica

Xiao Y. Wei; Chung Y. Leung; Chris K C WONG; Xiao L. Shen; Ricky N S WONG; Zongwei CAI; Nai Ki MAK

doi:10.1021/np049662i

Bisindigotin, a TCDD antagonist from the Chinese medicinal herb Isatis indigotica

Xiao Y. Wei, Chung Y. Leung, Chris K C WONG, Xiao L. Shen, Ricky N S WONG, Zongwei CAI, Nai Ki MAK^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

36 Citations (Scopus)

Abstract

A new indigoid derivative, bisindigotin (1), with 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD)-antagonistic activity was isolated from the ethanol extract of the Chinese medicinal herb Isatis indigotica. Its structure was determined by spectroscopic methods. In the human HepG2 hepatoma cell model, 1 (50 nM to 2 μM) was found to dose-dependently inhibit TCDD-induced ethoxyresorufin O-deethylase (EROD) activity.

Original language	English
Pages (from-to)	427-429
Number of pages	3
Journal	Journal of Natural Products
Volume	68
Issue number	3
DOIs	https://doi.org/10.1021/np049662i
Publication status	Published - Mar 2005

Scopus Subject Areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np049662i

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title = "Bisindigotin, a TCDD antagonist from the Chinese medicinal herb Isatis indigotica",

abstract = "A new indigoid derivative, bisindigotin (1), with 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD)-antagonistic activity was isolated from the ethanol extract of the Chinese medicinal herb Isatis indigotica. Its structure was determined by spectroscopic methods. In the human HepG2 hepatoma cell model, 1 (50 nM to 2 μM) was found to dose-dependently inhibit TCDD-induced ethoxyresorufin O-deethylase (EROD) activity.",

author = "Wei, {Xiao Y.} and Leung, {Chung Y.} and WONG, {Chris K C} and Shen, {Xiao L.} and WONG, {Ricky N S} and Zongwei CAI and MAK, {Nai Ki}",

note = "This work was supported by a Group Research-Central Allocation and an earmarked research grant (project number HKBU 2036/00M) from the Research Grant Council of Hong Kong. ",

year = "2005",

month = mar,

doi = "10.1021/np049662i",

language = "English",

volume = "68",

pages = "427--429",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

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T1 - Bisindigotin, a TCDD antagonist from the Chinese medicinal herb Isatis indigotica

AU - Wei, Xiao Y.

AU - Leung, Chung Y.

AU - WONG, Chris K C

AU - Shen, Xiao L.

AU - WONG, Ricky N S

AU - CAI, Zongwei

AU - MAK, Nai Ki

N1 - This work was supported by a Group Research-Central Allocation and an earmarked research grant (project number HKBU 2036/00M) from the Research Grant Council of Hong Kong.

PY - 2005/3

Y1 - 2005/3

N2 - A new indigoid derivative, bisindigotin (1), with 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD)-antagonistic activity was isolated from the ethanol extract of the Chinese medicinal herb Isatis indigotica. Its structure was determined by spectroscopic methods. In the human HepG2 hepatoma cell model, 1 (50 nM to 2 μM) was found to dose-dependently inhibit TCDD-induced ethoxyresorufin O-deethylase (EROD) activity.

AB - A new indigoid derivative, bisindigotin (1), with 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD)-antagonistic activity was isolated from the ethanol extract of the Chinese medicinal herb Isatis indigotica. Its structure was determined by spectroscopic methods. In the human HepG2 hepatoma cell model, 1 (50 nM to 2 μM) was found to dose-dependently inhibit TCDD-induced ethoxyresorufin O-deethylase (EROD) activity.

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U2 - 10.1021/np049662i

DO - 10.1021/np049662i

M3 - Journal article

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AN - SCOPUS:17444420285

SN - 0163-3864

VL - 68

SP - 427

EP - 429

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 3

ER -

Bisindigotin, a TCDD antagonist from the Chinese medicinal herb Isatis indigotica

Abstract

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