Bisindigotin, a TCDD antagonist from the Chinese medicinal herb Isatis indigotica

Xiao Y. Wei, Chung Y. Leung, Chris K C WONG, Xiao L. Shen, Ricky N S WONG, Zongwei CAI, Nai Ki MAK*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

35 Citations (Scopus)


A new indigoid derivative, bisindigotin (1), with 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD)-antagonistic activity was isolated from the ethanol extract of the Chinese medicinal herb Isatis indigotica. Its structure was determined by spectroscopic methods. In the human HepG2 hepatoma cell model, 1 (50 nM to 2 μM) was found to dose-dependently inhibit TCDD-induced ethoxyresorufin O-deethylase (EROD) activity.

Original languageEnglish
Pages (from-to)427-429
Number of pages3
JournalJournal of Natural Products
Issue number3
Publication statusPublished - Mar 2005

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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