Biotransformation of ginsenosides Rb1, Rg3 and Rh2 in rat gastrointestinal tracts

Tianxiu Qian; Zongwei CAI

doi:10.1186/1749-8546-5-19

Biotransformation of ginsenosides Rb₁, Rg₃and Rh₂in rat gastrointestinal tracts

Tianxiu Qian, Zongwei CAI^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

25 Citations (Scopus)

Abstract

Background: Ginsenosides such as Rb₁, Rg₃and Rh₂are major bioactive components of Panax ginseng. This in vivo study investigates the metabolic pathways of ginsenosides Rb₁, Rg₃and Rh₂orally administered to rats.Methods: High performance liquid chromatography-mass spectrometry (LC-MS) and tandem mass spectrometry (MS-MS) techniques, particularly liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS), were used to identify the metabolites.Results: Six metabolites of Rb₁, six metabolites of Rg₃and three metabolites of Rh₂were detected in the feces samples of the rats. Rh₂was a metabolite of Rb₁and Rg₃, whereas Rg₃was a metabolite of Rb₁. Some metabolites such as protopanaxadiol and monooxygenated protopanaxadiol are metabolites of all three ginsenosides.Conclusion: Oxygenation and deglycosylation are two major metabolic pathways of the ginsenosides in rat gastrointestinal tracts.

Original language	English
Article number	19
Journal	Chinese Medicine
Volume	5
DOIs	https://doi.org/10.1186/1749-8546-5-19
Publication status	Published - 26 May 2010

Scopus Subject Areas

Pharmacology
Complementary and alternative medicine

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title = "Biotransformation of ginsenosides Rb1, Rg3 and Rh2 in rat gastrointestinal tracts",

abstract = "Background: Ginsenosides such as Rb1, Rg3 and Rh2 are major bioactive components of Panax ginseng. This in vivo study investigates the metabolic pathways of ginsenosides Rb1, Rg3 and Rh2 orally administered to rats.Methods: High performance liquid chromatography-mass spectrometry (LC-MS) and tandem mass spectrometry (MS-MS) techniques, particularly liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS), were used to identify the metabolites.Results: Six metabolites of Rb1, six metabolites of Rg3 and three metabolites of Rh2 were detected in the feces samples of the rats. Rh2 was a metabolite of Rb1 and Rg3, whereas Rg3 was a metabolite of Rb1. Some metabolites such as protopanaxadiol and monooxygenated protopanaxadiol are metabolites of all three ginsenosides.Conclusion: Oxygenation and deglycosylation are two major metabolic pathways of the ginsenosides in rat gastrointestinal tracts.",

author = "Tianxiu Qian and Zongwei CAI",

year = "2010",

month = may,

day = "26",

doi = "10.1186/1749-8546-5-19",

language = "English",

volume = "5",

journal = "Chinese Medicine",

issn = "1749-8546",

publisher = "BioMed Central Ltd.",

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TY - JOUR

T1 - Biotransformation of ginsenosides Rb1, Rg3 and Rh2 in rat gastrointestinal tracts

AU - Qian, Tianxiu

AU - CAI, Zongwei

PY - 2010/5/26

Y1 - 2010/5/26

N2 - Background: Ginsenosides such as Rb1, Rg3 and Rh2 are major bioactive components of Panax ginseng. This in vivo study investigates the metabolic pathways of ginsenosides Rb1, Rg3 and Rh2 orally administered to rats.Methods: High performance liquid chromatography-mass spectrometry (LC-MS) and tandem mass spectrometry (MS-MS) techniques, particularly liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS), were used to identify the metabolites.Results: Six metabolites of Rb1, six metabolites of Rg3 and three metabolites of Rh2 were detected in the feces samples of the rats. Rh2 was a metabolite of Rb1 and Rg3, whereas Rg3 was a metabolite of Rb1. Some metabolites such as protopanaxadiol and monooxygenated protopanaxadiol are metabolites of all three ginsenosides.Conclusion: Oxygenation and deglycosylation are two major metabolic pathways of the ginsenosides in rat gastrointestinal tracts.

AB - Background: Ginsenosides such as Rb1, Rg3 and Rh2 are major bioactive components of Panax ginseng. This in vivo study investigates the metabolic pathways of ginsenosides Rb1, Rg3 and Rh2 orally administered to rats.Methods: High performance liquid chromatography-mass spectrometry (LC-MS) and tandem mass spectrometry (MS-MS) techniques, particularly liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS), were used to identify the metabolites.Results: Six metabolites of Rb1, six metabolites of Rg3 and three metabolites of Rh2 were detected in the feces samples of the rats. Rh2 was a metabolite of Rb1 and Rg3, whereas Rg3 was a metabolite of Rb1. Some metabolites such as protopanaxadiol and monooxygenated protopanaxadiol are metabolites of all three ginsenosides.Conclusion: Oxygenation and deglycosylation are two major metabolic pathways of the ginsenosides in rat gastrointestinal tracts.

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DO - 10.1186/1749-8546-5-19

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SN - 1749-8546

VL - 5

JO - Chinese Medicine

JF - Chinese Medicine

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Biotransformation of ginsenosides Rb₁, Rg₃and Rh₂in rat gastrointestinal tracts

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