Biotransformation of Dioscorea nipponica by Rat Intestinal Microflora and Cardioprotective Effects of Diosgenin

Jia Fu Feng; Yi Na Tang; Hong Ji; Zhan Gang Xiao; Lin Zhu; Tao Yi

doi:10.1155/2017/4176518

Biotransformation of Dioscorea nipponica by Rat Intestinal Microflora and Cardioprotective Effects of Diosgenin

Jia Fu Feng, Yi Na Tang, Hong Ji, Zhan Gang Xiao, Lin Zhu^*, Tao Yi^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

29 Citations (Scopus)

54 Downloads (Pure)

Abstract

Studying the biotransformation of natural products by intestinal microflora is an important approach to understanding how and why some medicines - particularly natural medicines - work. In many cases, the active components are generated by metabolic activation. This is critical for drug research and development. As a means to explore the therapeutic mechanism of Dioscorea nipponica (DN), a medicinal plant used to treat myocardial ischemia (MI), metabolites generated by intestinal microflora from DN were identified, and the cardioprotective efficacy of these metabolites was evaluated. Our results demonstrate that diosgenin is the main metabolite produced by rat intestinal microflora from DN. Further, our results show that diosgenin protects the myocardium against ischemic insult through increasing enzymatic and nonenzymatic antioxidant levels in vivo and by decreasing oxidative stress damage. These mechanisms explain the clinical efficacy of DN as an anti-MI drug.

Original language	English
Article number	4176518
Journal	Oxidative Medicine and Cellular Longevity
Volume	2017
DOIs	https://doi.org/10.1155/2017/4176518
Publication status	Published - 30 Sept 2017

Scopus Subject Areas

Biochemistry
Ageing
Cell Biology

Access to Document

10.1155/2017/4176518

Full TextFinal published version, 3.82 MB

Cite this

@article{24863031419b4f31b779ea0ddcc61cea,

title = "Biotransformation of Dioscorea nipponica by Rat Intestinal Microflora and Cardioprotective Effects of Diosgenin",

abstract = "Studying the biotransformation of natural products by intestinal microflora is an important approach to understanding how and why some medicines - particularly natural medicines - work. In many cases, the active components are generated by metabolic activation. This is critical for drug research and development. As a means to explore the therapeutic mechanism of Dioscorea nipponica (DN), a medicinal plant used to treat myocardial ischemia (MI), metabolites generated by intestinal microflora from DN were identified, and the cardioprotective efficacy of these metabolites was evaluated. Our results demonstrate that diosgenin is the main metabolite produced by rat intestinal microflora from DN. Further, our results show that diosgenin protects the myocardium against ischemic insult through increasing enzymatic and nonenzymatic antioxidant levels in vivo and by decreasing oxidative stress damage. These mechanisms explain the clinical efficacy of DN as an anti-MI drug.",

author = "Feng, {Jia Fu} and Tang, {Yi Na} and Hong Ji and Xiao, {Zhan Gang} and Lin Zhu and Tao Yi",

note = "Funding Information: This work was partially supported by the National Natural Science Foundation of China (81603381, 81673691), the Guangdong Natural Science Foundation (2014A030313766, 2016A030313008), the Science and Technology Planning Project of Guangdong Province (2015A020211039), the Shenzhen Science and Technology Innovation Committee (JCYJ20160518094706544), and the Faculty Research Grant of Hong Kong Baptist University (FRG2/15-16/022).",

year = "2017",

month = sep,

day = "30",

doi = "10.1155/2017/4176518",

language = "English",

volume = "2017",

journal = "Oxidative Medicine and Cellular Longevity",

issn = "1942-0900",

publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Biotransformation of Dioscorea nipponica by Rat Intestinal Microflora and Cardioprotective Effects of Diosgenin

AU - Feng, Jia Fu

AU - Tang, Yi Na

AU - Ji, Hong

AU - Xiao, Zhan Gang

AU - Zhu, Lin

AU - Yi, Tao

N1 - Funding Information: This work was partially supported by the National Natural Science Foundation of China (81603381, 81673691), the Guangdong Natural Science Foundation (2014A030313766, 2016A030313008), the Science and Technology Planning Project of Guangdong Province (2015A020211039), the Shenzhen Science and Technology Innovation Committee (JCYJ20160518094706544), and the Faculty Research Grant of Hong Kong Baptist University (FRG2/15-16/022).

PY - 2017/9/30

Y1 - 2017/9/30

N2 - Studying the biotransformation of natural products by intestinal microflora is an important approach to understanding how and why some medicines - particularly natural medicines - work. In many cases, the active components are generated by metabolic activation. This is critical for drug research and development. As a means to explore the therapeutic mechanism of Dioscorea nipponica (DN), a medicinal plant used to treat myocardial ischemia (MI), metabolites generated by intestinal microflora from DN were identified, and the cardioprotective efficacy of these metabolites was evaluated. Our results demonstrate that diosgenin is the main metabolite produced by rat intestinal microflora from DN. Further, our results show that diosgenin protects the myocardium against ischemic insult through increasing enzymatic and nonenzymatic antioxidant levels in vivo and by decreasing oxidative stress damage. These mechanisms explain the clinical efficacy of DN as an anti-MI drug.

AB - Studying the biotransformation of natural products by intestinal microflora is an important approach to understanding how and why some medicines - particularly natural medicines - work. In many cases, the active components are generated by metabolic activation. This is critical for drug research and development. As a means to explore the therapeutic mechanism of Dioscorea nipponica (DN), a medicinal plant used to treat myocardial ischemia (MI), metabolites generated by intestinal microflora from DN were identified, and the cardioprotective efficacy of these metabolites was evaluated. Our results demonstrate that diosgenin is the main metabolite produced by rat intestinal microflora from DN. Further, our results show that diosgenin protects the myocardium against ischemic insult through increasing enzymatic and nonenzymatic antioxidant levels in vivo and by decreasing oxidative stress damage. These mechanisms explain the clinical efficacy of DN as an anti-MI drug.

UR - http://www.scopus.com/inward/record.url?scp=85030762902&partnerID=8YFLogxK

U2 - 10.1155/2017/4176518

DO - 10.1155/2017/4176518

M3 - Journal article

C2 - 29085554

AN - SCOPUS:85030762902

SN - 1942-0900

VL - 2017

JO - Oxidative Medicine and Cellular Longevity

JF - Oxidative Medicine and Cellular Longevity

M1 - 4176518

ER -

Biotransformation of Dioscorea nipponica by Rat Intestinal Microflora and Cardioprotective Effects of Diosgenin

Abstract

Scopus Subject Areas

Access to Document

Other files and links

Fingerprint

Cite this