Bi(OTf)3-catalyzed addition of isocyanides to 2H-chromene acetals: An efficient pathway for accessing 2-carboxamide-2H-chromenes

Longyun Lyu, Ming Yu Jin, Qijie He, Han Xie, Zhaoxiang BIAN, Jun WANG*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Bismuth triflate (Bi(OTf)3) is identified as an efficient catalyst for the direct addition of isocyanides to 2H-chromene acetals. The large scope of isocyanides and chromene acetals makes them suitable substrates in this catalytic system. By this synthetic strategy, a polyfunctional molecular scaffold, 2-carboxamide-2H-chromenes could be prepared efficiently in one step up to 95% yield. In addition, this efficient and practical protocol proceeded smoothly in the gram scale even when the catalytic loading was reduced to 2 mol%.

Original languageEnglish
Pages (from-to)8088-8091
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number34
DOIs
Publication statusPublished - 14 Sep 2016

Scopus Subject Areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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