Bioprospecting and bioassay-guided isolation of medicinal plants—A tool for drug discovery

Chen Liang Zhao, Wai I. Chik, Hong Jie Zhang

Research output: Chapter in book/report/conference proceedingChapterpeer-review

4 Citations (Scopus)

Abstract

Medicinal plants have been serving as vital sources for drug discovery. A significant proportion of clinically approved drugs are originated from plant-derived natural products which were isolated by chromatographic techniques and identified by spectroscopic analysis. Bioactivity-guided fractionation is considered an efficient approach for retrieving active chemical constituents and pure compounds from medicinal plants. In search of more potential drug candidates, various drug discovery programs have been launched. These include the University of Illinois at Chicago based International Cooperative Biodiversity Groups (UIC-ICBG) program and Lingnan region drug discovery program, in which numerous bioactive molecules have been isolated and identified. They will be discussed in this chapter as examples to highlight the use of the bioassay-guided separation tool to efficiently obtain the bioactive compounds from thousands of plant extracts. A range of simple, rapid and commonly used bioassays in research laboratories as well as medicinal plant-derived natural products will also be delineated.

Original languageEnglish
Title of host publicationEvidence-Based Validation of Herbal Medicine
Subtitle of host publicationTranslational Research on Botanicals
EditorsPulok Mukherjee
PublisherElsevier
Chapter22
Pages511-537
Number of pages27
Edition2nd
ISBN (Electronic)9780323984560
ISBN (Print)9780323855426
DOIs
Publication statusPublished - 12 Jul 2022

Scopus Subject Areas

  • Economics, Econometrics and Finance(all)
  • Business, Management and Accounting(all)

User-Defined Keywords

  • Anti-bacterial agents
  • Anti-cancer agents
  • Anti-parasitic agents
  • Anti-viral agents
  • Bioactive lead compounds
  • Bioassay-guided isolation
  • In vitro screening assays
  • Lingnan plants
  • The UIC-ICBG program

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