@article{0330ea8fd7ed42bcadbd38c30a8b94ee,
title = "Biomimetic multifunctional persistent luminescence nanoprobes for long-term near-infrared imaging and therapy of cerebral and cerebellar gliomas",
abstract = "Glioma is the most common malignant primary brain tumor, and the accurate diagnosis of glioma has always been a challenge. Moreover, cerebellar glioma, which is difficult to be detected by magnetic resonance imaging, is not usually diagnosed until after the appearance of clinical symptoms. In this study, TRZD, a near-infrared (NIR) persistent luminescence (PL) nanoparticle with a dual function of imaging and therapy, was synthesized based on ZnGa2O4:Cr3+,Sn4+. TRZD showed excellent rechargeable NIR PL for more than 30 hours in vivo with good tissue penetration for long-term autofluorescence-free imaging. The tumor growth of both the subcutaneous and orthotropic glioma models was significantly inhibited by TRZD. This is the first-time approach using NIR PL nanoprobes for both diagnosis and therapy of glioma. This is also the first-time report of nanotechnology-based diagnosis and therapy of cerebellar gliomas. This study offers a highly promising multifunctional nanoparticle for theranostics of a wide range of brain diseases.",
author = "Jianglong Kong and Rui Zou and Law, {Ga Lai} and Yi Wang",
note = "Funding Information: Acknowledgments Funding: This work is financially supported by the General Research Fund of Hong Kong (15304119 to G.-L.L. and Y.W. and 15334316 and 12302921 to Y.W.), the Health and Medical Research Fund of the Food and Health Bureau of Hong Kong (05161016 and 07183026 to Y.W.), and the Environmental and Conservation Fund of the Environment Protection Department of Hong Kong (2020-48 to Y.W.). Author contributions: Y.W. conceived the idea and designed the experiments. J.K. and R.Z. performed the experiments. J.K. and G.-L.L. analyzed the data. G.-L.L. provided suggestions on the research. Y.W. and J.K. wrote the paper. All authors contributed to the general discussion. Competing interests: The authors declare that they have no competing interests. Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. Publisher Copyright: Copyright {\textcopyright} 2022 The Authors",
year = "2022",
month = mar,
day = "11",
doi = "10.1126/sciadv.abm7077",
language = "English",
volume = "8",
journal = "Science Advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "10",
}