Biomechanopharmacology: a new borderline discipline

Fulong Liao; Min LI; Dong Han; Jun Cao; Keji Chen

doi:10.1016/j.tips.2006.04.001

Biomechanopharmacology: a new borderline discipline

Fulong Liao^*
, Min LI
, Dong Han
, Jun Cao
, Keji Chen

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Journal article › peer-review

34 Citations (Scopus)

Abstract

Flowing blood is more than a drug transporter in pharmacology; its mechanical impact should also be considered. The in vitro pharmacological dose-response pattern of endothelial cellular functions can be significantly modified by in vivo shear stress. A new borderline discipline, biomechanopharmacology, is forming at the boundary between biomechanics and pharmacology. Biomechanopharmacology will probably consist of both the pharmacological intervention of signals induced by biomechanical factors and the biomechanical influence on pharmacokinetics and pharmacodynamics, in addition to the joint effect of biomechanical and pharmacological factors. Recent investigations show that exercise enhances the shear of pulsatile blood flow to stimulate angiogenesis. The benefits of exercise for gaining joint biomechanical and pharmacological effects should be emphasized.

Original language	English
Pages (from-to)	287-289
Number of pages	3
Journal	Trends in Pharmacological Sciences
Volume	27
Issue number	6
Early online date	6 May 2006
DOIs	https://doi.org/10.1016/j.tips.2006.04.001
Publication status	Published - Jun 2006

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10.1016/j.tips.2006.04.001

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title = "Biomechanopharmacology: a new borderline discipline",

abstract = "Flowing blood is more than a drug transporter in pharmacology; its mechanical impact should also be considered. The in vitro pharmacological dose-response pattern of endothelial cellular functions can be significantly modified by in vivo shear stress. A new borderline discipline, biomechanopharmacology, is forming at the boundary between biomechanics and pharmacology. Biomechanopharmacology will probably consist of both the pharmacological intervention of signals induced by biomechanical factors and the biomechanical influence on pharmacokinetics and pharmacodynamics, in addition to the joint effect of biomechanical and pharmacological factors. Recent investigations show that exercise enhances the shear of pulsatile blood flow to stimulate angiogenesis. The benefits of exercise for gaining joint biomechanical and pharmacological effects should be emphasized.",

author = "Fulong Liao and Min LI and Dong Han and Jun Cao and Keji Chen",

note = "Funding Information: This research was supported in part by grants from Natural Science Foundation of China (10272116 and 90209055), 973 Project (04051J1173) and Faculty Research Grant of Hong Kong Baptist University (03–04/II-53 and 03–04/II-26). We appreciate the guidance of Zhengang Wang from Peking Union Medical College.",

year = "2006",

month = jun,

doi = "10.1016/j.tips.2006.04.001",

language = "English",

volume = "27",

pages = "287--289",

journal = "Trends in Pharmacological Sciences",

issn = "0165-6147",

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T1 - Biomechanopharmacology

T2 - a new borderline discipline

AU - Liao, Fulong

AU - LI, Min

AU - Han, Dong

AU - Cao, Jun

AU - Chen, Keji

N1 - Funding Information: This research was supported in part by grants from Natural Science Foundation of China (10272116 and 90209055), 973 Project (04051J1173) and Faculty Research Grant of Hong Kong Baptist University (03–04/II-53 and 03–04/II-26). We appreciate the guidance of Zhengang Wang from Peking Union Medical College.

PY - 2006/6

Y1 - 2006/6

N2 - Flowing blood is more than a drug transporter in pharmacology; its mechanical impact should also be considered. The in vitro pharmacological dose-response pattern of endothelial cellular functions can be significantly modified by in vivo shear stress. A new borderline discipline, biomechanopharmacology, is forming at the boundary between biomechanics and pharmacology. Biomechanopharmacology will probably consist of both the pharmacological intervention of signals induced by biomechanical factors and the biomechanical influence on pharmacokinetics and pharmacodynamics, in addition to the joint effect of biomechanical and pharmacological factors. Recent investigations show that exercise enhances the shear of pulsatile blood flow to stimulate angiogenesis. The benefits of exercise for gaining joint biomechanical and pharmacological effects should be emphasized.

AB - Flowing blood is more than a drug transporter in pharmacology; its mechanical impact should also be considered. The in vitro pharmacological dose-response pattern of endothelial cellular functions can be significantly modified by in vivo shear stress. A new borderline discipline, biomechanopharmacology, is forming at the boundary between biomechanics and pharmacology. Biomechanopharmacology will probably consist of both the pharmacological intervention of signals induced by biomechanical factors and the biomechanical influence on pharmacokinetics and pharmacodynamics, in addition to the joint effect of biomechanical and pharmacological factors. Recent investigations show that exercise enhances the shear of pulsatile blood flow to stimulate angiogenesis. The benefits of exercise for gaining joint biomechanical and pharmacological effects should be emphasized.

UR - https://www.scopus.com/pages/publications/33744938141

U2 - 10.1016/j.tips.2006.04.001

DO - 10.1016/j.tips.2006.04.001

M3 - Journal article

C2 - 16678914

AN - SCOPUS:33744938141

SN - 0165-6147

VL - 27

SP - 287

EP - 289

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

IS - 6

ER -

Biomechanopharmacology: a new borderline discipline

Abstract

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