TY - JOUR
T1 - Biomechanopharmacology
T2 - a new borderline discipline
AU - Liao, Fulong
AU - LI, Min
AU - Han, Dong
AU - Cao, Jun
AU - Chen, Keji
N1 - Funding Information:
This research was supported in part by grants from Natural Science Foundation of China (10272116 and 90209055), 973 Project (04051J1173) and Faculty Research Grant of Hong Kong Baptist University (03–04/II-53 and 03–04/II-26). We appreciate the guidance of Zhengang Wang from Peking Union Medical College.
PY - 2006/6
Y1 - 2006/6
N2 - Flowing blood is more than a drug transporter in pharmacology; its mechanical impact should also be considered. The in vitro pharmacological dose-response pattern of endothelial cellular functions can be significantly modified by in vivo shear stress. A new borderline discipline, biomechanopharmacology, is forming at the boundary between biomechanics and pharmacology. Biomechanopharmacology will probably consist of both the pharmacological intervention of signals induced by biomechanical factors and the biomechanical influence on pharmacokinetics and pharmacodynamics, in addition to the joint effect of biomechanical and pharmacological factors. Recent investigations show that exercise enhances the shear of pulsatile blood flow to stimulate angiogenesis. The benefits of exercise for gaining joint biomechanical and pharmacological effects should be emphasized.
AB - Flowing blood is more than a drug transporter in pharmacology; its mechanical impact should also be considered. The in vitro pharmacological dose-response pattern of endothelial cellular functions can be significantly modified by in vivo shear stress. A new borderline discipline, biomechanopharmacology, is forming at the boundary between biomechanics and pharmacology. Biomechanopharmacology will probably consist of both the pharmacological intervention of signals induced by biomechanical factors and the biomechanical influence on pharmacokinetics and pharmacodynamics, in addition to the joint effect of biomechanical and pharmacological factors. Recent investigations show that exercise enhances the shear of pulsatile blood flow to stimulate angiogenesis. The benefits of exercise for gaining joint biomechanical and pharmacological effects should be emphasized.
UR - http://www.scopus.com/inward/record.url?scp=33744938141&partnerID=8YFLogxK
U2 - 10.1016/j.tips.2006.04.001
DO - 10.1016/j.tips.2006.04.001
M3 - Journal article
C2 - 16678914
AN - SCOPUS:33744938141
SN - 0165-6147
VL - 27
SP - 287
EP - 289
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 6
ER -