Biomechanopharmacology: a new borderline discipline

Fulong Liao*, Min LI, Dong Han, Jun Cao, Keji Chen

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

26 Citations (Scopus)

Abstract

Flowing blood is more than a drug transporter in pharmacology; its mechanical impact should also be considered. The in vitro pharmacological dose-response pattern of endothelial cellular functions can be significantly modified by in vivo shear stress. A new borderline discipline, biomechanopharmacology, is forming at the boundary between biomechanics and pharmacology. Biomechanopharmacology will probably consist of both the pharmacological intervention of signals induced by biomechanical factors and the biomechanical influence on pharmacokinetics and pharmacodynamics, in addition to the joint effect of biomechanical and pharmacological factors. Recent investigations show that exercise enhances the shear of pulsatile blood flow to stimulate angiogenesis. The benefits of exercise for gaining joint biomechanical and pharmacological effects should be emphasized.

Original languageEnglish
Pages (from-to)287-289
Number of pages3
JournalTrends in Pharmacological Sciences
Volume27
Issue number6
DOIs
Publication statusPublished - Jun 2006

Scopus Subject Areas

  • Toxicology
  • Pharmacology

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