Biological Applications of Supramolecular Coordination Complexes

Chung Hang Leung; Tian Shu Kang; Chao Yang; Ka Ho Leung; Dik Lung Ma

doi:10.1016/B978-0-12-409547-2.12558-2

Biological Applications of Supramolecular Coordination Complexes

Chung Hang Leung^*
, Tian Shu Kang
, Chao Yang
, Ka Ho Leung
, Dik Lung Ma

^*Corresponding author for this work

Department of Chemistry

Research output: Chapter in book/report/conference proceeding › Chapter › peer-review

6 Citations (Scopus)

Abstract

Mononuclear metal complexes, particularly those based on platinum and ruthenium metal centers, have attracted tremendous attention over recent decades for therapeutic purposes, particular anticancer therapy. However, inorganic architectures based on supramolecular coordination complexes (SCCs) have received comparatively less attention for biological applications. In this chapter, we highlight recent examples of SCCs that interact with DNA or protein through different binding modes and/or exhibit cytotoxic activity against cancer cell lines.

Original language	English
Title of host publication	Supramolecular Medicinal Chemistry and Chemical Biology
Publisher	Elsevier Inc.
Pages	3-20
Number of pages	18
Volume	5
ISBN (Electronic)	9780128031988
ISBN (Print)	9780128031995
DOIs	https://doi.org/10.1016/B978-0-12-409547-2.12558-2
Publication status	Published - 22 Jun 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

Anticancer
Biological
Coordination
Drug
Inorganic
Medicinal chemistry
Metal complex
Supramolecular
Therapeutic
Transition metal

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10.1016/B978-0-12-409547-2.12558-2

Cite this

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title = "Biological Applications of Supramolecular Coordination Complexes",

abstract = "Mononuclear metal complexes, particularly those based on platinum and ruthenium metal centers, have attracted tremendous attention over recent decades for therapeutic purposes, particular anticancer therapy. However, inorganic architectures based on supramolecular coordination complexes (SCCs) have received comparatively less attention for biological applications. In this chapter, we highlight recent examples of SCCs that interact with DNA or protein through different binding modes and/or exhibit cytotoxic activity against cancer cell lines.",

keywords = "Anticancer, Biological, Coordination, Drug, Inorganic, Medicinal chemistry, Metal complex, Supramolecular, Therapeutic, Transition metal",

author = "Leung, \{Chung Hang\} and Kang, \{Tian Shu\} and Chao Yang and Leung, \{Ka Ho\} and Ma, \{Dik Lung\}",

year = "2017",

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doi = "10.1016/B978-0-12-409547-2.12558-2",

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TY - CHAP

T1 - Biological Applications of Supramolecular Coordination Complexes

AU - Leung, Chung Hang

AU - Kang, Tian Shu

AU - Yang, Chao

AU - Leung, Ka Ho

AU - Ma, Dik Lung

PY - 2017/6/22

Y1 - 2017/6/22

N2 - Mononuclear metal complexes, particularly those based on platinum and ruthenium metal centers, have attracted tremendous attention over recent decades for therapeutic purposes, particular anticancer therapy. However, inorganic architectures based on supramolecular coordination complexes (SCCs) have received comparatively less attention for biological applications. In this chapter, we highlight recent examples of SCCs that interact with DNA or protein through different binding modes and/or exhibit cytotoxic activity against cancer cell lines.

AB - Mononuclear metal complexes, particularly those based on platinum and ruthenium metal centers, have attracted tremendous attention over recent decades for therapeutic purposes, particular anticancer therapy. However, inorganic architectures based on supramolecular coordination complexes (SCCs) have received comparatively less attention for biological applications. In this chapter, we highlight recent examples of SCCs that interact with DNA or protein through different binding modes and/or exhibit cytotoxic activity against cancer cell lines.

KW - Anticancer

KW - Biological

KW - Coordination

KW - Drug

KW - Inorganic

KW - Medicinal chemistry

KW - Metal complex

KW - Supramolecular

KW - Therapeutic

KW - Transition metal

UR - https://www.scopus.com/pages/publications/85046118074

U2 - 10.1016/B978-0-12-409547-2.12558-2

DO - 10.1016/B978-0-12-409547-2.12558-2

M3 - Chapter

AN - SCOPUS:85046118074

SN - 9780128031995

VL - 5

SP - 3

EP - 20

BT - Supramolecular Medicinal Chemistry and Chemical Biology

PB - Elsevier Inc.

ER -

Biological Applications of Supramolecular Coordination Complexes

Abstract

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