Biological and microcalorimetric studies of the toxic effect of organoarsenic(V) compounds to wild strain of Bacillus thuringiensis

Mohammad Russel; Jun Yao; Huilun Chen; Fei Wang; Yong Zhou; Rensheng Zhuang; Martin M.F. Choi; Brunello Ceccanti; Polonca Trebse; Gyula Zaray

doi:10.1007/s12011-009-8358-1

Biological and microcalorimetric studies of the toxic effect of organoarsenic(V) compounds to wild strain of Bacillus thuringiensis

Mohammad Russel, Jun Yao^*, Huilun Chen, Fei Wang, Yong Zhou, Rensheng Zhuang, Martin M.F. Choi, Brunello Ceccanti, Polonca Trebse, Gyula Zaray

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

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Abstract

Microcalorimetric and biological methods were carried out to determine the toxicity of dimethylarsinic acid (DMA) and monomethylarsonic acid (MMA) to wild strain of Bacillus thuringiensis. Thermokinetic parameters were obtained from the power-time curves, showing that the peak-heat output power, total heat output, and number of colonies decreased with the increases in concentration of DMA and MMA. In addition, the generation time and peak maximal time increased with the increases in the dosage of DMA and MMA. The half inhibitory concentrations of DMA and MMA were 99.02 and 142.02 λ.gmL-1, respectively for the wild strain of B. thuringiensis. DMA shows higher toxicity to bacteria than MMA. The toxicity resistance of B. thuringiensis against organoarsenic(V) is quite high for the wild strain. Our work demonstrates that micro-calorimetry is a very sensitive, simple, and useful technique for in vitro investigation of the toxic effect of organoarsenic(V) on microbial activity.

Original language	English
Pages (from-to)	192-203
Number of pages	12
Journal	Biological Trace Element Research
Volume	131
Issue number	2
DOIs	https://doi.org/10.1007/s12011-009-8358-1
Publication status	Published - Nov 2009

Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Clinical Biochemistry
Biochemistry, medical
Inorganic Chemistry

User-Defined Keywords

Bacillus thuringiensis
Half inhibitory doses
Microcalorimetry
Optical density
Toxicity

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12011-009-8358-1

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title = "Biological and microcalorimetric studies of the toxic effect of organoarsenic(V) compounds to wild strain of Bacillus thuringiensis",

abstract = "Microcalorimetric and biological methods were carried out to determine the toxicity of dimethylarsinic acid (DMA) and monomethylarsonic acid (MMA) to wild strain of Bacillus thuringiensis. Thermokinetic parameters were obtained from the power-time curves, showing that the peak-heat output power, total heat output, and number of colonies decreased with the increases in concentration of DMA and MMA. In addition, the generation time and peak maximal time increased with the increases in the dosage of DMA and MMA. The half inhibitory concentrations of DMA and MMA were 99.02 and 142.02 λ.gmL-1, respectively for the wild strain of B. thuringiensis. DMA shows higher toxicity to bacteria than MMA. The toxicity resistance of B. thuringiensis against organoarsenic(V) is quite high for the wild strain. Our work demonstrates that micro-calorimetry is a very sensitive, simple, and useful technique for in vitro investigation of the toxic effect of organoarsenic(V) on microbial activity.",

keywords = "Bacillus thuringiensis, Half inhibitory doses, Microcalorimetry, Optical density, Toxicity",

author = "Mohammad Russel and Jun Yao and Huilun Chen and Fei Wang and Yong Zhou and Rensheng Zhuang and Choi, {Martin M.F.} and Brunello Ceccanti and Polonca Trebse and Gyula Zaray",

note = "Funding Information: Acknowledgments This work was supported in part by grants from the Sino-Italian, Sino-German PPP, Sino-Hungarian, Sino-Slovenian Governmental International Scientific and Technological Cooperation Project (200625, 20063139, 2006294, and 2007203), National Natural Science Foundation of China (40425001 and 40673065), the Specialized Research Fund for the Doctoral Program of Higher Education (20060491508), the Key Project of Chinese Ministry of Education (107077), the Hubei Key International Cooperation Project (2006CA007), and 111 project (B08030).",

year = "2009",

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doi = "10.1007/s12011-009-8358-1",

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AU - Russel, Mohammad

AU - Yao, Jun

AU - Chen, Huilun

AU - Wang, Fei

AU - Zhou, Yong

AU - Zhuang, Rensheng

AU - Choi, Martin M.F.

AU - Ceccanti, Brunello

AU - Trebse, Polonca

AU - Zaray, Gyula

N1 - Funding Information: Acknowledgments This work was supported in part by grants from the Sino-Italian, Sino-German PPP, Sino-Hungarian, Sino-Slovenian Governmental International Scientific and Technological Cooperation Project (200625, 20063139, 2006294, and 2007203), National Natural Science Foundation of China (40425001 and 40673065), the Specialized Research Fund for the Doctoral Program of Higher Education (20060491508), the Key Project of Chinese Ministry of Education (107077), the Hubei Key International Cooperation Project (2006CA007), and 111 project (B08030).

PY - 2009/11

Y1 - 2009/11

N2 - Microcalorimetric and biological methods were carried out to determine the toxicity of dimethylarsinic acid (DMA) and monomethylarsonic acid (MMA) to wild strain of Bacillus thuringiensis. Thermokinetic parameters were obtained from the power-time curves, showing that the peak-heat output power, total heat output, and number of colonies decreased with the increases in concentration of DMA and MMA. In addition, the generation time and peak maximal time increased with the increases in the dosage of DMA and MMA. The half inhibitory concentrations of DMA and MMA were 99.02 and 142.02 λ.gmL-1, respectively for the wild strain of B. thuringiensis. DMA shows higher toxicity to bacteria than MMA. The toxicity resistance of B. thuringiensis against organoarsenic(V) is quite high for the wild strain. Our work demonstrates that micro-calorimetry is a very sensitive, simple, and useful technique for in vitro investigation of the toxic effect of organoarsenic(V) on microbial activity.

AB - Microcalorimetric and biological methods were carried out to determine the toxicity of dimethylarsinic acid (DMA) and monomethylarsonic acid (MMA) to wild strain of Bacillus thuringiensis. Thermokinetic parameters were obtained from the power-time curves, showing that the peak-heat output power, total heat output, and number of colonies decreased with the increases in concentration of DMA and MMA. In addition, the generation time and peak maximal time increased with the increases in the dosage of DMA and MMA. The half inhibitory concentrations of DMA and MMA were 99.02 and 142.02 λ.gmL-1, respectively for the wild strain of B. thuringiensis. DMA shows higher toxicity to bacteria than MMA. The toxicity resistance of B. thuringiensis against organoarsenic(V) is quite high for the wild strain. Our work demonstrates that micro-calorimetry is a very sensitive, simple, and useful technique for in vitro investigation of the toxic effect of organoarsenic(V) on microbial activity.

KW - Bacillus thuringiensis

KW - Half inhibitory doses

KW - Microcalorimetry

KW - Optical density

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SN - 0163-4984

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Biological and microcalorimetric studies of the toxic effect of organoarsenic(V) compounds to wild strain of Bacillus thuringiensis

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