Biological and clinical implications of herbal medicine and natural products for the treatment of inflammatory bowel disease

Bao Jian Guo, Zhaoxiang BIAN, Hong Cong Qiu, Yi Tao Wang*, Ying Wang

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

37 Citations (Scopus)

Abstract

Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders that includes Crohn's disease (CD) and ulcerative colitis (UC). Homeostasis of various regulatory factors involved with intestinal immunity is disrupted in IBD, including the intestinal epithelial barrier, macrophages, and cellular mediators such as cytokines and chemokines. No successful treatment is currently available for the management of IBD. Natural products and herbal medicines have exhibited efficacy for UC and CD in experimental models and clinical trials with the following activities: (1) maintenance of integrity of the intestinal epithelial barrier, (2) regulation of macrophage activation, (3) modulation of innate and adaptive immune response, and (4) inhibition of TNF-α activity. Here, we discuss the major factors involved in the pathogenesis of IBD and the current development of natural products and herbs for the treatment of IBD.

Original languageEnglish
Pages (from-to)37-48
Number of pages12
JournalAnnals of the New York Academy of Sciences
Volume1401
Issue number1
DOIs
Publication statusPublished - 2017

Scopus Subject Areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

User-Defined Keywords

  • Crohn's disease
  • herbal medicine
  • inflammatory bowel disease
  • natural products
  • ulcerative colitis

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