Biocompatible CdSe quantum dot-based photosensitizer under two-photon excitation for photodynamic therapy

Zu De Qi; Dong Wei Li; Peng Jiang; Feng Lei Jiang; Yue Sheng Li; Yi Liu; Rick W K WONG; Kok Wai CHEAH

doi:10.1039/c0jm03229h

Biocompatible CdSe quantum dot-based photosensitizer under two-photon excitation for photodynamic therapy

Zu De Qi
, Dong Wei Li
, Peng Jiang
, Feng Lei Jiang
, Yue Sheng Li
, Yi Liu^*
, Rick W K WONG
, Kok Wai CHEAH

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

87 Citations (Scopus)

Abstract

An enhanced photosensitizer combining biocompatible CdSe quantum dots (QDs) with water-soluble porphyrin was synthesized by a facile method. The two photon absorption (TPA) cross-section values of the QDs range from 800 to 2400 Goeppert-Mayer units (GM), depending on the excitation wavelength, calculated by the standard method using R6G as a reference. The singlet oxygen generation under two-photon excitation (TPE) in the QD-porphyrin system was two times greater than that in the porphyrin solution alone. This study underlines the potential of QD-based photosensitizers for biological applications in TPE photodynamic therapy.

Original language	English
Pages (from-to)	2455-2458
Number of pages	4
Journal	Journal of Materials Chemistry
Volume	21
Issue number	8
DOIs	https://doi.org/10.1039/c0jm03229h
Publication status	Published - 28 Feb 2011

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@article{8887fc5de3084f168222dd65b0f50a01,

title = "Biocompatible CdSe quantum dot-based photosensitizer under two-photon excitation for photodynamic therapy",

abstract = "An enhanced photosensitizer combining biocompatible CdSe quantum dots (QDs) with water-soluble porphyrin was synthesized by a facile method. The two photon absorption (TPA) cross-section values of the QDs range from 800 to 2400 Goeppert-Mayer units (GM), depending on the excitation wavelength, calculated by the standard method using R6G as a reference. The singlet oxygen generation under two-photon excitation (TPE) in the QD-porphyrin system was two times greater than that in the porphyrin solution alone. This study underlines the potential of QD-based photosensitizers for biological applications in TPE photodynamic therapy.",

author = "Qi, \{Zu De\} and Li, \{Dong Wei\} and Peng Jiang and Jiang, \{Feng Lei\} and Li, \{Yue Sheng\} and Yi Liu and WONG, \{Rick W K\} and CHEAH, \{Kok Wai\}",

note = "This work was supported by the financial support of the National Natural Science Foundation of China (Grant No. 20873096, 20921062, 20621502), Chinese 973 Program (2011CB933600) and the Fundamental Research Funds for the Central Universities (No. 1103005, 1101007, 3081001).",

year = "2011",

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day = "28",

doi = "10.1039/c0jm03229h",

language = "English",

volume = "21",

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journal = "Journal of Materials Chemistry",

issn = "0959-9428",

publisher = "Royal Society of Chemistry",

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T1 - Biocompatible CdSe quantum dot-based photosensitizer under two-photon excitation for photodynamic therapy

AU - Qi, Zu De

AU - Li, Dong Wei

AU - Jiang, Peng

AU - Jiang, Feng Lei

AU - Li, Yue Sheng

AU - Liu, Yi

AU - WONG, Rick W K

AU - CHEAH, Kok Wai

N1 - This work was supported by the financial support of the National Natural Science Foundation of China (Grant No. 20873096, 20921062, 20621502), Chinese 973 Program (2011CB933600) and the Fundamental Research Funds for the Central Universities (No. 1103005, 1101007, 3081001).

PY - 2011/2/28

Y1 - 2011/2/28

N2 - An enhanced photosensitizer combining biocompatible CdSe quantum dots (QDs) with water-soluble porphyrin was synthesized by a facile method. The two photon absorption (TPA) cross-section values of the QDs range from 800 to 2400 Goeppert-Mayer units (GM), depending on the excitation wavelength, calculated by the standard method using R6G as a reference. The singlet oxygen generation under two-photon excitation (TPE) in the QD-porphyrin system was two times greater than that in the porphyrin solution alone. This study underlines the potential of QD-based photosensitizers for biological applications in TPE photodynamic therapy.

AB - An enhanced photosensitizer combining biocompatible CdSe quantum dots (QDs) with water-soluble porphyrin was synthesized by a facile method. The two photon absorption (TPA) cross-section values of the QDs range from 800 to 2400 Goeppert-Mayer units (GM), depending on the excitation wavelength, calculated by the standard method using R6G as a reference. The singlet oxygen generation under two-photon excitation (TPE) in the QD-porphyrin system was two times greater than that in the porphyrin solution alone. This study underlines the potential of QD-based photosensitizers for biological applications in TPE photodynamic therapy.

UR - https://www.scopus.com/pages/publications/79751492953

U2 - 10.1039/c0jm03229h

DO - 10.1039/c0jm03229h

M3 - Journal article

AN - SCOPUS:79751492953

SN - 0959-9428

VL - 21

SP - 2455

EP - 2458

JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

IS - 8

ER -

Biocompatible CdSe quantum dot-based photosensitizer under two-photon excitation for photodynamic therapy

Abstract

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