Biocompatible CdSe quantum dot-based photosensitizer under two-photon excitation for photodynamic therapy

Zu De Qi; Dong Wei Li; Peng Jiang; Feng Lei Jiang; Yue Sheng Li; Yi Liu; Rick W K WONG; Kok Wai CHEAH

doi:10.1039/c0jm03229h

Biocompatible CdSe quantum dot-based photosensitizer under two-photon excitation for photodynamic therapy

Zu De Qi, Dong Wei Li, Peng Jiang, Feng Lei Jiang, Yue Sheng Li, Yi Liu^*, Rick W K WONG, Kok Wai CHEAH

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

82 Citations (Scopus)

Abstract

An enhanced photosensitizer combining biocompatible CdSe quantum dots (QDs) with water-soluble porphyrin was synthesized by a facile method. The two photon absorption (TPA) cross-section values of the QDs range from 800 to 2400 Goeppert-Mayer units (GM), depending on the excitation wavelength, calculated by the standard method using R6G as a reference. The singlet oxygen generation under two-photon excitation (TPE) in the QD-porphyrin system was two times greater than that in the porphyrin solution alone. This study underlines the potential of QD-based photosensitizers for biological applications in TPE photodynamic therapy.

Original language	English
Pages (from-to)	2455-2458
Number of pages	4
Journal	Journal of Materials Chemistry
Volume	21
Issue number	8
DOIs	https://doi.org/10.1039/c0jm03229h
Publication status	Published - 28 Feb 2011

Scopus Subject Areas

Chemistry(all)
Materials Chemistry

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title = "Biocompatible CdSe quantum dot-based photosensitizer under two-photon excitation for photodynamic therapy",

abstract = "An enhanced photosensitizer combining biocompatible CdSe quantum dots (QDs) with water-soluble porphyrin was synthesized by a facile method. The two photon absorption (TPA) cross-section values of the QDs range from 800 to 2400 Goeppert-Mayer units (GM), depending on the excitation wavelength, calculated by the standard method using R6G as a reference. The singlet oxygen generation under two-photon excitation (TPE) in the QD-porphyrin system was two times greater than that in the porphyrin solution alone. This study underlines the potential of QD-based photosensitizers for biological applications in TPE photodynamic therapy.",

author = "Qi, {Zu De} and Li, {Dong Wei} and Peng Jiang and Jiang, {Feng Lei} and Li, {Yue Sheng} and Yi Liu and WONG, {Rick W K} and CHEAH, {Kok Wai}",

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T1 - Biocompatible CdSe quantum dot-based photosensitizer under two-photon excitation for photodynamic therapy

AU - Qi, Zu De

AU - Li, Dong Wei

AU - Jiang, Peng

AU - Jiang, Feng Lei

AU - Li, Yue Sheng

AU - Liu, Yi

AU - WONG, Rick W K

AU - CHEAH, Kok Wai

PY - 2011/2/28

Y1 - 2011/2/28

N2 - An enhanced photosensitizer combining biocompatible CdSe quantum dots (QDs) with water-soluble porphyrin was synthesized by a facile method. The two photon absorption (TPA) cross-section values of the QDs range from 800 to 2400 Goeppert-Mayer units (GM), depending on the excitation wavelength, calculated by the standard method using R6G as a reference. The singlet oxygen generation under two-photon excitation (TPE) in the QD-porphyrin system was two times greater than that in the porphyrin solution alone. This study underlines the potential of QD-based photosensitizers for biological applications in TPE photodynamic therapy.

AB - An enhanced photosensitizer combining biocompatible CdSe quantum dots (QDs) with water-soluble porphyrin was synthesized by a facile method. The two photon absorption (TPA) cross-section values of the QDs range from 800 to 2400 Goeppert-Mayer units (GM), depending on the excitation wavelength, calculated by the standard method using R6G as a reference. The singlet oxygen generation under two-photon excitation (TPE) in the QD-porphyrin system was two times greater than that in the porphyrin solution alone. This study underlines the potential of QD-based photosensitizers for biological applications in TPE photodynamic therapy.

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U2 - 10.1039/c0jm03229h

DO - 10.1039/c0jm03229h

M3 - Journal article

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SN - 0959-9428

VL - 21

SP - 2455

EP - 2458

JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

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ER -

Biocompatible CdSe quantum dot-based photosensitizer under two-photon excitation for photodynamic therapy

Abstract

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