Bioassay-guided isolation of xanthones and polycyclic prenylated acylphloroglucinols from Garcinia oblongifolia

Sheng-Xiong Huang, Chao Feng, Yan Zhou, Gang Xu, Quan-Bin Han, Chun Feng Qiao, Donald C. Chang, Kathy Qian Luo, Hong-Xi Xu

Research output: Contribution to journalJournal articlepeer-review

71 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the acetone extract of the bark of Garcinia oblongifolia has resulted in the isolation of three new xanthones, oblongixanthones A-C (1-3), three new polyprenylated benzoylphloroglucinols, oblongifolins E-G (4-6), and 12 known compounds. Oblongifolins I (5) and J (6) are the first natural products that have similar structural features to those of two known oxidation products of garcinol. The structures of the new compounds 1-6 were characterized by spectroscopic data interpretation. All isolates were assayed for their apoptosis-inducing effects against HeLa-C3 cells. Oblongifolin C (16) was found to be the most potent apoptotic inducer of the compounds evaluated.
Original languageEnglish
Pages (from-to)130-135
Number of pages6
JournalJournal of Natural Products
Volume72
Issue number1
DOIs
Publication statusPublished - Jan 2009

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