TY - JOUR
T1 - Bioactive proteins and peptides isolated from Chinese medicines with pharmaceutical potential
AU - Wong, Kam Lok
AU - Wong, Ricky Ngok Shun
AU - Zhang, Liang
AU - Liu, Wing Keung
AU - Ng, Tzi Bun
AU - Shaw, Pang Chui
AU - Kwok, Philip Chi Lip
AU - Lai, Yau Ming
AU - Zhang, Zhang Jin
AU - Zhang, Yanbo
AU - Tong, Yao
AU - Cheung, Ho Pan
AU - Lu, Jia
AU - Sze, Stephen Cho Wing
N1 - Funding information:
This study was partially supported by grants from the Innovation and Technology Fund (ITF), project no ITS/262/09FP, of the Innovation and Technology Commission, Government of Hong Kong Special Administrative Region; and Seed Funding Programme for Basic Research, Project codes: 200707176177, 201011159213 and 201111159222, the University of Hong Kong. We also thank our ITF sponsors, including Oriental International Health Products Company Limited, and Hong Kong Ma Sai Leung Tong Medicine Manufacturing Limited, which are our collaborating organizations in the Innovation and Technology project.
Publisher copyright:
© 2014 Wong et al.; licensee BioMed Central Ltd.
PY - 2014/7/19
Y1 - 2014/7/19
N2 - Some protein pharmaceuticals from Chinese medicine have been developed to treat cardiovascular diseases, genetic diseases, and cancer. Bioactive proteins with various pharmacological properties have been successfully isolated from animals such as Hirudo medicinalis (medicinal leech), Eisenia fetida (earthworm), and Mesobuthus martensii (Chinese scorpion), and from herbal medicines derived from species such as Cordyceps militaris, Ganoderma, Momordica cochinchinensis, Viscum album, Poria cocos, Senna obtusifolia, Panax notoginseng, Smilax glabra, Ginkgo biloba, Dioscorea batatas, and Trichosanthes kirilowii. This article reviews the isolation methods, molecular characteristics, bioactivities, pharmacological properties, and potential uses of bioactive proteins originating from these Chinese medicines.
AB - Some protein pharmaceuticals from Chinese medicine have been developed to treat cardiovascular diseases, genetic diseases, and cancer. Bioactive proteins with various pharmacological properties have been successfully isolated from animals such as Hirudo medicinalis (medicinal leech), Eisenia fetida (earthworm), and Mesobuthus martensii (Chinese scorpion), and from herbal medicines derived from species such as Cordyceps militaris, Ganoderma, Momordica cochinchinensis, Viscum album, Poria cocos, Senna obtusifolia, Panax notoginseng, Smilax glabra, Ginkgo biloba, Dioscorea batatas, and Trichosanthes kirilowii. This article reviews the isolation methods, molecular characteristics, bioactivities, pharmacological properties, and potential uses of bioactive proteins originating from these Chinese medicines.
KW - Chinese Medicine
KW - Bivalirudin
KW - Fibrinolytic Enzyme
KW - Fast Protein Liquid Chromatography
KW - Viscum Album
UR - http://www.scopus.com/inward/record.url?scp=84904520078&partnerID=8YFLogxK
U2 - 10.1186/1749-8546-9-19
DO - 10.1186/1749-8546-9-19
M3 - Review article
AN - SCOPUS:84904520078
SN - 1749-8546
VL - 9
JO - Chinese Medicine
JF - Chinese Medicine
M1 - 19
ER -
