TY - JOUR
T1 - Bioactive natural compounds against human coronaviruses
T2 - a review and perspective
AU - Xian, Yanfang
AU - Zhang, Juan
AU - Bian, Zhaoxiang
AU - Zhou, Hua
AU - Zhang, Zhenbiao
AU - Lin, Zhixiu
AU - Xu, Hongxi
N1 - Publisher Copyright:
© 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences
PY - 2020/7
Y1 - 2020/7
N2 - Coronaviruses (CoVs), a family of enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, unusually large RNA genome, and unique replication capability. CoVs are known to cause various potentially lethal human respiratory infectious diseases, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and the very recent coronavirus disease 2019 (COVID-19) outbreak. Unfortunately, neither drug nor vaccine has yet been approved to date to prevent and treat these diseases caused by CoVs. Therefore, effective prevention and treatment medications against human coronavirus are in urgent need. In the past decades, many natural compounds have been reported to possess multiple biological activities, including antiviral properties. In this article, we provided a comprehensive review on the natural compounds that interfere with the life cycles of SARS and MERS, and discussed their potential use for the treatment of COVID-19.
AB - Coronaviruses (CoVs), a family of enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, unusually large RNA genome, and unique replication capability. CoVs are known to cause various potentially lethal human respiratory infectious diseases, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and the very recent coronavirus disease 2019 (COVID-19) outbreak. Unfortunately, neither drug nor vaccine has yet been approved to date to prevent and treat these diseases caused by CoVs. Therefore, effective prevention and treatment medications against human coronavirus are in urgent need. In the past decades, many natural compounds have been reported to possess multiple biological activities, including antiviral properties. In this article, we provided a comprehensive review on the natural compounds that interfere with the life cycles of SARS and MERS, and discussed their potential use for the treatment of COVID-19.
KW - Coronavirus
KW - COVID-19
KW - MERS-CoV
KW - Natural compounds
KW - RNA-Virus
KW - SARS-CoV
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85087288383&partnerID=8YFLogxK
U2 - 10.1016/j.apsb.2020.06.002
DO - 10.1016/j.apsb.2020.06.002
M3 - Review article
AN - SCOPUS:85087288383
SN - 2211-3835
VL - 10
SP - 1163
EP - 1174
JO - Acta Pharmaceutica Sinica B
JF - Acta Pharmaceutica Sinica B
IS - 7
ER -
