Bioactive luminescent transition-metal complexes for biomedical applications

Edmond Dik Lung MA*, Hong Zhang He, Ka Ho Leung, Daniel Shiu Hin Chan, Chung Hang Leung

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

257 Citations (Scopus)

Abstract

The serendipitous discovery of the anticancer drug cisplatin cemented medicinal inorganic chemistry as an independent discipline in the 1960s. Luminescent metal complexes have subsequently been widely applied for sensing, bio-imaging, and in organic light-emitting diode applications. Transition-metal complexes possess a variety of advantages that make them suitable as therapeutics and as luminescent probes for biomolecules. It is thus highly desirable to develop new luminescent metal complexes that either interact with DNA through different binding modes or target alternative cellular machinery such as proteins as well as to provide a more effective means of monitoring disease progression. In this Review, we highlight recent examples of biologically active luminescent metal complexes that can target and probe a specific biomolecule, and offer insights into the future potential of these compounds for the investigation and treatment of human diseases. Metal-based theranostics: This Review highlights recent examples of biologically active luminescent metal complexes that can target and probe a specific biomolecule, and offers insight into the future potential of luminescent metal-based therapeutics for the investigation and treatment of human diseases.

Original languageEnglish
Pages (from-to)7666-7682
Number of pages17
JournalAngewandte Chemie. International Edition
Volume52
Issue number30
DOIs
Publication statusPublished - 22 Jul 2013

Scopus Subject Areas

  • Catalysis
  • Chemistry(all)

User-Defined Keywords

  • luminescence
  • metal complexes
  • theranostics
  • therapeutic agent
  • transition metals

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