Bioactive iridium and rhodium complexes as therapeutic agents

Chung Hang Leung*, Hai Jing Zhong, Daniel Shiu Hin Chan, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

203 Citations (Scopus)

Abstract

Group 9 metal complexes based on iridium and rhodium have recently arisen as fascinating potential alternatives to existing platinum and ruthenium metallodrugs. While long regarded as chemically inert, studies over the past few years have demonstrated that the reactivity and biological activity of iridium and rhodium complexes may be unlocked by a suitable choice of auxiliary ligands. In addition, group 9 metal centers have received increased popularity for the construction of kinetically inert organometallic scaffolds as target-selective protein or enzyme inhibitors. In this review, we summarize the recent strategies that have been utilized for the design and development of bioactive iridium and rhodium complexes.

Original languageEnglish
Pages (from-to)1764-1776
Number of pages13
JournalCoordination Chemistry Reviews
Volume257
Issue number11-12
DOIs
Publication statusPublished - Jun 2013

Scopus Subject Areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

User-Defined Keywords

  • Anti-cancer
  • Inorganic medicine
  • Iridium
  • Metallodrug
  • Rhodium

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