@article{f600c12cf5064fc08a773ac046185f8d,
title = "Bioactive icetexane and abietane diterpenes from Isodon phyllopodus",
abstract = "A new icetexane diterpenoid, 11, 12, 20α-trihydroxyl-7β-methoxyicetexa-8, 11, 13-triene-19, 10-lactone [Phyllane A (1)], and a new abietane diterpenoid, 7β, 20-epoxy-3β, 17-acetoxy-abieta-8, 11, 13-teriene-11, 12-diol [phyllane B (2)], along with two known compounds (3 and 4) were isolated from the methanol (MeOH) extract of twigs and leaves of the folk medicinal Isodon phyllopodus. Their structures were determined by spectroscopic analyses including 2 D NMR spectral data, and further confirmed by X-ray single crystal diffraction. Moreover, the compounds were evaluated for their cytotoxicity and anti-HIV activities, and phyllane A showed anti-HIV activity with an IC50 value of 15.7 μM, but phyllane B was found to be cytotoxic to the A549 host cells with a CC50 value of 108.5 μM.",
keywords = "anti-HIV activity, crystal structure, cytotoxicity, diterpenoids, folk medicine, Isodon phyllopodus",
author = "Rui Deng and Juan Zou and Zhao, \{Chen Liang\} and Yang, \{Ye Meng\} and Ku, \{Chuen Fai\} and Yu Zhu and Liang, \{Zheng Ming\} and Ye, \{Jiang Hai\} and Pan, \{Lu Tai\} and Zhang, \{Hong Jie\}",
note = "Funding information: This project was funded by the National Natural Science Foundation of China (No. 81260635), the National Natural Science Foundation of China (No. 81760772), the Domestic First-Rate Fund of China GNYL(2017)008, National Key R\&D Program of China [2019YFC1712500], the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. HKBU 12102219), Hong Kong Baptist University, Research Committee, Initiation Grant – Faculty Niche Research Areas (RC-IG-FNRA/17-18/12), and University Grants Committee of the Hong Kong Special Administrative Region, China (UGC Research Matching Grant Scheme RMGS2019\_1\_19). Publisher Copyright: {\textcopyright} 2021 Informa UK Limited, trading as Taylor \& Francis Group.",
year = "2023",
month = jan,
day = "2",
doi = "10.1080/14786419.2021.1950716",
language = "English",
volume = "37",
pages = "68--76",
journal = "Natural Product Research",
issn = "1478-6419",
publisher = "Taylor and Francis Ltd.",
number = "1",
}
