TY - JOUR
T1 - Bioactive icetexane and abietane diterpenes from Isodon phyllopodus
AU - Deng, Rui
AU - Zou, Juan
AU - Zhao, Chen Liang
AU - Yang, Ye Meng
AU - Ku, Chuen Fai
AU - Zhu, Yu
AU - Liang, Zheng Ming
AU - Ye, Jiang Hai
AU - Pan, Lu Tai
AU - Zhang, Hong Jie
N1 - Funding information:
This project was funded by the National Natural Science Foundation of China (No. 81260635), the National Natural Science Foundation of China (No. 81760772), the Domestic First-Rate Fund of China GNYL(2017)008, National Key R&D Program of China [2019YFC1712500], the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. HKBU 12102219), Hong Kong Baptist University, Research Committee, Initiation Grant – Faculty Niche Research Areas (RC-IG-FNRA/17-18/12), and University Grants Committee of the Hong Kong Special Administrative Region, China (UGC Research Matching Grant Scheme RMGS2019_1_19).
Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2023/1/2
Y1 - 2023/1/2
N2 - A new icetexane diterpenoid, 11, 12, 20α-trihydroxyl-7β-methoxyicetexa-8, 11, 13-triene-19, 10-lactone [Phyllane A (1)], and a new abietane diterpenoid, 7β, 20-epoxy-3β, 17-acetoxy-abieta-8, 11, 13-teriene-11, 12-diol [phyllane B (2)], along with two known compounds (3 and 4) were isolated from the methanol (MeOH) extract of twigs and leaves of the folk medicinal Isodon phyllopodus. Their structures were determined by spectroscopic analyses including 2 D NMR spectral data, and further confirmed by X-ray single crystal diffraction. Moreover, the compounds were evaluated for their cytotoxicity and anti-HIV activities, and phyllane A showed anti-HIV activity with an IC50 value of 15.7 μM, but phyllane B was found to be cytotoxic to the A549 host cells with a CC50 value of 108.5 μM.
AB - A new icetexane diterpenoid, 11, 12, 20α-trihydroxyl-7β-methoxyicetexa-8, 11, 13-triene-19, 10-lactone [Phyllane A (1)], and a new abietane diterpenoid, 7β, 20-epoxy-3β, 17-acetoxy-abieta-8, 11, 13-teriene-11, 12-diol [phyllane B (2)], along with two known compounds (3 and 4) were isolated from the methanol (MeOH) extract of twigs and leaves of the folk medicinal Isodon phyllopodus. Their structures were determined by spectroscopic analyses including 2 D NMR spectral data, and further confirmed by X-ray single crystal diffraction. Moreover, the compounds were evaluated for their cytotoxicity and anti-HIV activities, and phyllane A showed anti-HIV activity with an IC50 value of 15.7 μM, but phyllane B was found to be cytotoxic to the A549 host cells with a CC50 value of 108.5 μM.
KW - anti-HIV activity
KW - crystal structure
KW - cytotoxicity
KW - diterpenoids
KW - folk medicine
KW - Isodon phyllopodus
UR - https://www.ingentaconnect.com/content/tandf/gnp/2023/00000037/00000001/art00010
UR - http://www.scopus.com/inward/record.url?scp=85110702621&partnerID=8YFLogxK
U2 - 10.1080/14786419.2021.1950716
DO - 10.1080/14786419.2021.1950716
M3 - Journal article
C2 - 34498960
AN - SCOPUS:85110702621
SN - 1478-6419
VL - 37
SP - 68
EP - 76
JO - Natural Product Research
JF - Natural Product Research
IS - 1
ER -
