Bioactive icetexane and abietane diterpenes from Isodon phyllopodus

Rui Deng, Juan Zou, Chen Liang Zhao, Ye Meng Yang, Chuen Fai Ku, Yu Zhu, Zheng Ming Liang, Jiang Hai Ye, Lu Tai Pan*, Hong Jie Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A new icetexane diterpenoid, 11, 12, 20α-trihydroxyl-7β-methoxyicetexa-8, 11, 13-triene-19, 10-lactone [Phyllane A (1)], and a new abietane diterpenoid, 7β, 20-epoxy-3β, 17-acetoxy-abieta-8, 11, 13-teriene-11, 12-diol [phyllane B (2)], along with two known compounds (3 and 4) were isolated from the methanol (MeOH) extract of twigs and leaves of the folk medicinal Isodon phyllopodus. Their structures were determined by spectroscopic analyses including 2 D NMR spectral data, and further confirmed by X-ray single crystal diffraction. Moreover, the compounds were evaluated for their cytotoxicity and anti-HIV activities, and phyllane A showed anti-HIV activity with an IC50 value of 15.7 μM, but phyllane B was found to be cytotoxic to the A549 host cells with a CC50 value of 108.5 μM.

Original languageEnglish
JournalNatural Product Research
DOIs
Publication statusE-pub ahead of print - 9 Sep 2021

Scopus Subject Areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

User-Defined Keywords

  • anti-HIV activity
  • crystal structure
  • cytotoxicity
  • diterpenoids
  • folk medicine
  • Isodon phyllopodus

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