Bioactive icetexane and abietane diterpenes from Isodon phyllopodus

Rui Deng; Juan Zou; Chen Liang  Zhao; Ye Meng Yang; Chuen Fai  Ku; Yu Zhu; Zheng Ming Liang; Jiang Hai Ye; Lu Tai  Pan; Hong Jie  Zhang

doi:10.1080/14786419.2021.1950716

Bioactive icetexane and abietane diterpenes from Isodon phyllopodus

Rui Deng, Juan Zou, Chen Liang Zhao, Ye Meng Yang, Chuen Fai Ku, Yu Zhu, Zheng Ming Liang, Jiang Hai Ye, Lu Tai Pan^*, Hong Jie Zhang^*

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A new icetexane diterpenoid, 11, 12, 20α-trihydroxyl-7β-methoxyicetexa-8, 11, 13-triene-19, 10-lactone [Phyllane A (1)], and a new abietane diterpenoid, 7β, 20-epoxy-3β, 17-acetoxy-abieta-8, 11, 13-teriene-11, 12-diol [phyllane B (2)], along with two known compounds (3 and 4) were isolated from the methanol (MeOH) extract of twigs and leaves of the folk medicinal Isodon phyllopodus. Their structures were determined by spectroscopic analyses including 2 D NMR spectral data, and further confirmed by X-ray single crystal diffraction. Moreover, the compounds were evaluated for their cytotoxicity and anti-HIV activities, and phyllane A showed anti-HIV activity with an IC₅₀ value of 15.7 μM, but phyllane B was found to be cytotoxic to the A549 host cells with a CC₅₀ value of 108.5 μM.

Original language	English
Journal	Natural Product Research
DOIs	https://doi.org/10.1080/14786419.2021.1950716
Publication status	E-pub ahead of print - 9 Sept 2021

Scopus Subject Areas

Analytical Chemistry
Biochemistry
Plant Science
Organic Chemistry

User-Defined Keywords

anti-HIV activity
crystal structure
cytotoxicity
diterpenoids
folk medicine
Isodon phyllopodus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/14786419.2021.1950716

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@article{f600c12cf5064fc08a773ac046185f8d,

title = "Bioactive icetexane and abietane diterpenes from Isodon phyllopodus",

abstract = "A new icetexane diterpenoid, 11, 12, 20α-trihydroxyl-7β-methoxyicetexa-8, 11, 13-triene-19, 10-lactone [Phyllane A (1)], and a new abietane diterpenoid, 7β, 20-epoxy-3β, 17-acetoxy-abieta-8, 11, 13-teriene-11, 12-diol [phyllane B (2)], along with two known compounds (3 and 4) were isolated from the methanol (MeOH) extract of twigs and leaves of the folk medicinal Isodon phyllopodus. Their structures were determined by spectroscopic analyses including 2 D NMR spectral data, and further confirmed by X-ray single crystal diffraction. Moreover, the compounds were evaluated for their cytotoxicity and anti-HIV activities, and phyllane A showed anti-HIV activity with an IC50 value of 15.7 μM, but phyllane B was found to be cytotoxic to the A549 host cells with a CC50 value of 108.5 μM.",

keywords = "anti-HIV activity, crystal structure, cytotoxicity, diterpenoids, folk medicine, Isodon phyllopodus",

author = "Rui Deng and Juan Zou and Zhao, {Chen Liang} and Yang, {Ye Meng} and Ku, {Chuen Fai} and Yu Zhu and Liang, {Zheng Ming} and Ye, {Jiang Hai} and Pan, {Lu Tai} and Zhang, {Hong Jie}",

note = "Funding information: This project was funded by the National Natural Science Foundation of China (No. 81260635), the National Natural Science Foundation of China (No. 81760772), the Domestic First-Rate Fund of China GNYL(2017)008, National Key R&D Program of China [2019YFC1712500], the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. HKBU 12102219), Hong Kong Baptist University, Research Committee, Initiation Grant – Faculty Niche Research Areas (RC-IG-FNRA/17-18/12), and University Grants Committee of the Hong Kong Special Administrative Region, China (UGC Research Matching Grant Scheme RMGS2019_1_19). Publisher Copyright: {\textcopyright} 2021 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2021",

month = sep,

day = "9",

doi = "10.1080/14786419.2021.1950716",

language = "English",

journal = "Natural Product Research",

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AU - Deng, Rui

AU - Zou, Juan

AU - Zhao, Chen Liang

AU - Yang, Ye Meng

AU - Ku, Chuen Fai

AU - Zhu, Yu

AU - Liang, Zheng Ming

AU - Ye, Jiang Hai

AU - Pan, Lu Tai

AU - Zhang, Hong Jie

N1 - Funding information: This project was funded by the National Natural Science Foundation of China (No. 81260635), the National Natural Science Foundation of China (No. 81760772), the Domestic First-Rate Fund of China GNYL(2017)008, National Key R&D Program of China [2019YFC1712500], the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. HKBU 12102219), Hong Kong Baptist University, Research Committee, Initiation Grant – Faculty Niche Research Areas (RC-IG-FNRA/17-18/12), and University Grants Committee of the Hong Kong Special Administrative Region, China (UGC Research Matching Grant Scheme RMGS2019_1_19). Publisher Copyright: © 2021 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2021/9/9

Y1 - 2021/9/9

N2 - A new icetexane diterpenoid, 11, 12, 20α-trihydroxyl-7β-methoxyicetexa-8, 11, 13-triene-19, 10-lactone [Phyllane A (1)], and a new abietane diterpenoid, 7β, 20-epoxy-3β, 17-acetoxy-abieta-8, 11, 13-teriene-11, 12-diol [phyllane B (2)], along with two known compounds (3 and 4) were isolated from the methanol (MeOH) extract of twigs and leaves of the folk medicinal Isodon phyllopodus. Their structures were determined by spectroscopic analyses including 2 D NMR spectral data, and further confirmed by X-ray single crystal diffraction. Moreover, the compounds were evaluated for their cytotoxicity and anti-HIV activities, and phyllane A showed anti-HIV activity with an IC50 value of 15.7 μM, but phyllane B was found to be cytotoxic to the A549 host cells with a CC50 value of 108.5 μM.

AB - A new icetexane diterpenoid, 11, 12, 20α-trihydroxyl-7β-methoxyicetexa-8, 11, 13-triene-19, 10-lactone [Phyllane A (1)], and a new abietane diterpenoid, 7β, 20-epoxy-3β, 17-acetoxy-abieta-8, 11, 13-teriene-11, 12-diol [phyllane B (2)], along with two known compounds (3 and 4) were isolated from the methanol (MeOH) extract of twigs and leaves of the folk medicinal Isodon phyllopodus. Their structures were determined by spectroscopic analyses including 2 D NMR spectral data, and further confirmed by X-ray single crystal diffraction. Moreover, the compounds were evaluated for their cytotoxicity and anti-HIV activities, and phyllane A showed anti-HIV activity with an IC50 value of 15.7 μM, but phyllane B was found to be cytotoxic to the A549 host cells with a CC50 value of 108.5 μM.

KW - anti-HIV activity

KW - crystal structure

KW - cytotoxicity

KW - diterpenoids

KW - folk medicine

KW - Isodon phyllopodus

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U2 - 10.1080/14786419.2021.1950716

DO - 10.1080/14786419.2021.1950716

M3 - Article

AN - SCOPUS:85110702621

SN - 1478-6419

JO - Natural Product Research

JF - Natural Product Research

ER -

Bioactive icetexane and abietane diterpenes from Isodon phyllopodus

Abstract

Scopus Subject Areas

User-Defined Keywords

UN SDGs

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