Bioactive dammarane triterpenes from the mangrove Plant Bruguiera gymnorrhiza

Sudarat Homhual, Nuntavan Bunyapraphatsara*, Tamara Kondratyuk, Angkana Herunsalee, Wongsatit Chaukul, John M. Pezzuto, Harry H.S. Fong, Hongjie ZHANG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Three new dammarane triterpenes, bruguierins A-C (1-3), were isolated from a petroleum ether extract of the flowers of Bruguiera gymnorrhiza. Their structures were determined on the basis of physical and spectroscopic data interpretation. With stably transfected HepG2 cells, the three isolates activated antioxidant response element (ARE luciferase activation) with EC50 values of 7.8, 9.4, and 15.7 μM, respectively. Bruguierin A (1) also inhibited phorbol ester-induced NFκB (nuclear factor-κB) luciferase activation with an IC50 value of 1.4 μM and selectively inhibited cyclooxygenase-2 (COX-2) activity with an IC50 value of 0.37 μM. Compounds 2 and 3 were not active in these bioassays.

Original languageEnglish
Pages (from-to)421-424
Number of pages4
JournalJournal of Natural Products
Volume69
Issue number3
DOIs
Publication statusPublished - Mar 2006

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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