TY - JOUR
T1 - Bioactive Constituents from Asparagus cochinchinensis
AU - Zhang, Hongjie
AU - Sydara, Kongmany
AU - Tan, Ghee Teng
AU - Ma, Cuiying
AU - Southavong, Bounhoong
AU - Soejarto, D. Doel
AU - Pezzuto, John M.
AU - Fong, Harry H.S.
N1 - The present study was supported by a grant administered by the Fogarty International Center, NIH (Grant 1 UO1-TW01015-01), as part of an International Cooperative Biodiversity Group (ICBG) program, through funds from NIH, NSF, and Foreign Agricultural Service of the USDA.
PY - 2004/2
Y1 - 2004/2
N2 - Bioassay-directed fractionation of the dried roots of Asparagus cochinchinensis led to the isolation of a new spirostanol saponin, asparacoside (1), two new C-27 spirosteroids, asparacosins A (2) and B (3), a new acetylenic derivative, 3″-methoxyasparenydiol (4), and a new polyphenol, 3′-hydroxy-4′-methoxy-4′-dehydroxynyasol (6), as well as five known phenolic compounds, asparenydiol (5), nyasol (7), 3″-methoxynyasol (8), 1,3-bis-di-p-hydroxyphenyl-4-penten-1-one (9), and trans-coniferyl alcohol (10). Compounds 1, 6, and 8 demonstrated moderate cytotoxicities in a panel comprised of KB, Col-2, LNCaP, Lu-1, and HUVEC cells, with IC50 values ranging from 4 to 12 μg/mL. The structures were determined by spectroscopic and chemical methods.
AB - Bioassay-directed fractionation of the dried roots of Asparagus cochinchinensis led to the isolation of a new spirostanol saponin, asparacoside (1), two new C-27 spirosteroids, asparacosins A (2) and B (3), a new acetylenic derivative, 3″-methoxyasparenydiol (4), and a new polyphenol, 3′-hydroxy-4′-methoxy-4′-dehydroxynyasol (6), as well as five known phenolic compounds, asparenydiol (5), nyasol (7), 3″-methoxynyasol (8), 1,3-bis-di-p-hydroxyphenyl-4-penten-1-one (9), and trans-coniferyl alcohol (10). Compounds 1, 6, and 8 demonstrated moderate cytotoxicities in a panel comprised of KB, Col-2, LNCaP, Lu-1, and HUVEC cells, with IC50 values ranging from 4 to 12 μg/mL. The structures were determined by spectroscopic and chemical methods.
UR - https://www.scopus.com/pages/publications/1442310136
U2 - 10.1021/np030370b
DO - 10.1021/np030370b
M3 - Journal article
C2 - 14987058
AN - SCOPUS:1442310136
SN - 0163-3864
VL - 67
SP - 194
EP - 200
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 2
ER -