Bioactive Constituents from Asparagus cochinchinensis

Hongjie ZHANG; Kongmany Sydara; Ghee Teng Tan; Cuiying Ma; Bounhoong Southavong; D. Doel Soejarto; John M. Pezzuto; Harry H.S. Fong

doi:10.1021/np030370b

Bioactive Constituents from Asparagus cochinchinensis

Hongjie ZHANG, Kongmany Sydara, Ghee Teng Tan, Cuiying Ma, Bounhoong Southavong, D. Doel Soejarto, John M. Pezzuto, Harry H.S. Fong^*

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Journal article › peer-review

69 Citations (Scopus)

Abstract

Bioassay-directed fractionation of the dried roots of Asparagus cochinchinensis led to the isolation of a new spirostanol saponin, asparacoside (1), two new C-27 spirosteroids, asparacosins A (2) and B (3), a new acetylenic derivative, 3″-methoxyasparenydiol (4), and a new polyphenol, 3′-hydroxy-4′-methoxy-4′-dehydroxynyasol (6), as well as five known phenolic compounds, asparenydiol (5), nyasol (7), 3″-methoxynyasol (8), 1,3-bis-di-p-hydroxyphenyl-4-penten-1-one (9), and trans-coniferyl alcohol (10). Compounds 1, 6, and 8 demonstrated moderate cytotoxicities in a panel comprised of KB, Col-2, LNCaP, Lu-1, and HUVEC cells, with IC₅₀ values ranging from 4 to 12 μg/mL. The structures were determined by spectroscopic and chemical methods.

Original language	English
Pages (from-to)	194-200
Number of pages	7
Journal	Journal of Natural Products
Volume	67
Issue number	2
DOIs	https://doi.org/10.1021/np030370b
Publication status	Published - Feb 2004

Scopus Subject Areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np030370b

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title = "Bioactive Constituents from Asparagus cochinchinensis",

abstract = "Bioassay-directed fractionation of the dried roots of Asparagus cochinchinensis led to the isolation of a new spirostanol saponin, asparacoside (1), two new C-27 spirosteroids, asparacosins A (2) and B (3), a new acetylenic derivative, 3″-methoxyasparenydiol (4), and a new polyphenol, 3′-hydroxy-4′-methoxy-4′-dehydroxynyasol (6), as well as five known phenolic compounds, asparenydiol (5), nyasol (7), 3″-methoxynyasol (8), 1,3-bis-di-p-hydroxyphenyl-4-penten-1-one (9), and trans-coniferyl alcohol (10). Compounds 1, 6, and 8 demonstrated moderate cytotoxicities in a panel comprised of KB, Col-2, LNCaP, Lu-1, and HUVEC cells, with IC50 values ranging from 4 to 12 μg/mL. The structures were determined by spectroscopic and chemical methods.",

author = "Hongjie ZHANG and Kongmany Sydara and Tan, {Ghee Teng} and Cuiying Ma and Bounhoong Southavong and Soejarto, {D. Doel} and Pezzuto, {John M.} and Fong, {Harry H.S.}",

year = "2004",

month = feb,

doi = "10.1021/np030370b",

language = "English",

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pages = "194--200",

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AU - ZHANG, Hongjie

AU - Sydara, Kongmany

AU - Tan, Ghee Teng

AU - Ma, Cuiying

AU - Southavong, Bounhoong

AU - Soejarto, D. Doel

AU - Pezzuto, John M.

AU - Fong, Harry H.S.

PY - 2004/2

Y1 - 2004/2

N2 - Bioassay-directed fractionation of the dried roots of Asparagus cochinchinensis led to the isolation of a new spirostanol saponin, asparacoside (1), two new C-27 spirosteroids, asparacosins A (2) and B (3), a new acetylenic derivative, 3″-methoxyasparenydiol (4), and a new polyphenol, 3′-hydroxy-4′-methoxy-4′-dehydroxynyasol (6), as well as five known phenolic compounds, asparenydiol (5), nyasol (7), 3″-methoxynyasol (8), 1,3-bis-di-p-hydroxyphenyl-4-penten-1-one (9), and trans-coniferyl alcohol (10). Compounds 1, 6, and 8 demonstrated moderate cytotoxicities in a panel comprised of KB, Col-2, LNCaP, Lu-1, and HUVEC cells, with IC50 values ranging from 4 to 12 μg/mL. The structures were determined by spectroscopic and chemical methods.

AB - Bioassay-directed fractionation of the dried roots of Asparagus cochinchinensis led to the isolation of a new spirostanol saponin, asparacoside (1), two new C-27 spirosteroids, asparacosins A (2) and B (3), a new acetylenic derivative, 3″-methoxyasparenydiol (4), and a new polyphenol, 3′-hydroxy-4′-methoxy-4′-dehydroxynyasol (6), as well as five known phenolic compounds, asparenydiol (5), nyasol (7), 3″-methoxynyasol (8), 1,3-bis-di-p-hydroxyphenyl-4-penten-1-one (9), and trans-coniferyl alcohol (10). Compounds 1, 6, and 8 demonstrated moderate cytotoxicities in a panel comprised of KB, Col-2, LNCaP, Lu-1, and HUVEC cells, with IC50 values ranging from 4 to 12 μg/mL. The structures were determined by spectroscopic and chemical methods.

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DO - 10.1021/np030370b

M3 - Journal article

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SP - 194

EP - 200

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 2

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Bioactive Constituents from Asparagus cochinchinensis

Abstract

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