Abstract
Bioassay-directed fractionation of the dried roots of Asparagus cochinchinensis led to the isolation of a new spirostanol saponin, asparacoside (1), two new C-27 spirosteroids, asparacosins A (2) and B (3), a new acetylenic derivative, 3″-methoxyasparenydiol (4), and a new polyphenol, 3′-hydroxy-4′-methoxy-4′-dehydroxynyasol (6), as well as five known phenolic compounds, asparenydiol (5), nyasol (7), 3″-methoxynyasol (8), 1,3-bis-di-p-hydroxyphenyl-4-penten-1-one (9), and trans-coniferyl alcohol (10). Compounds 1, 6, and 8 demonstrated moderate cytotoxicities in a panel comprised of KB, Col-2, LNCaP, Lu-1, and HUVEC cells, with IC50 values ranging from 4 to 12 μg/mL. The structures were determined by spectroscopic and chemical methods.
Original language | English |
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Pages (from-to) | 194-200 |
Number of pages | 7 |
Journal | Journal of Natural Products |
Volume | 67 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2004 |
Scopus Subject Areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry