Bioactive Constituents from Asparagus cochinchinensis

Hongjie ZHANG, Kongmany Sydara, Ghee Teng Tan, Cuiying Ma, Bounhoong Southavong, D. Doel Soejarto, John M. Pezzuto, Harry H.S. Fong*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

Bioassay-directed fractionation of the dried roots of Asparagus cochinchinensis led to the isolation of a new spirostanol saponin, asparacoside (1), two new C-27 spirosteroids, asparacosins A (2) and B (3), a new acetylenic derivative, 3″-methoxyasparenydiol (4), and a new polyphenol, 3′-hydroxy-4′-methoxy-4′-dehydroxynyasol (6), as well as five known phenolic compounds, asparenydiol (5), nyasol (7), 3″-methoxynyasol (8), 1,3-bis-di-p-hydroxyphenyl-4-penten-1-one (9), and trans-coniferyl alcohol (10). Compounds 1, 6, and 8 demonstrated moderate cytotoxicities in a panel comprised of KB, Col-2, LNCaP, Lu-1, and HUVEC cells, with IC50 values ranging from 4 to 12 μg/mL. The structures were determined by spectroscopic and chemical methods.

Original languageEnglish
Pages (from-to)194-200
Number of pages7
JournalJournal of Natural Products
Volume67
Issue number2
DOIs
Publication statusPublished - Feb 2004

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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