TY - JOUR
T1 - Bioactive compounds from the fern Lepisorus contortus
AU - Yang, Jian Hong
AU - Kondratyuk, Tamara P.
AU - Jermihov, Katherine C.
AU - Marler, Laura E.
AU - Qiu, Xi
AU - Choi, Yongsoo
AU - Cao, Hongmei
AU - Yu, Rui
AU - Sturdy, Megan
AU - Huang, Rong
AU - Liu, Ying
AU - Wang, Li Qin
AU - Mesecar, Andrew D.
AU - Van Breemen, Richard B.
AU - Pezzuto, John M.
AU - Fong, Harry H.S.
AU - Chen, Ye Gao
AU - Zhang, Hong Jie
N1 - This investigation was supported in part by program project P01 CA48112 awarded by the National Cancer Institute USA, a grant (2005DFA30670) for international collaborative research from the Chinese Ministry of Science and Technology, a grant (30560178) from the Natural Science Foundation of China, a Program for New Century Excellent Talents in University (NCET-05-0824), and the West Light Program from theChinese Academy of Sciences.
PY - 2011/2/25
Y1 - 2011/2/25
N2 - Phytochemical investigation of the whole plant of Lepisorus contortus (Christ) Ching led to the isolation of five new phenylethanoid glycosides (1-5), each containing a caffeoyl group, a new flavonoid glycoside (10), and 14 known compounds (6-9 and 11-15, syringic acid, vanillic acid, phloretic acid, diplopterol, and β-sitosterol). This is the first report of phenylethanoid glycosides from the family Polypodiaceae. Compounds 1-15 were evaluated for their cancer chemopreventive potential based on their ability to inhibit tumor necrosis factor alpha (TNF-α)-induced NF-κB activity, nitric oxide (NO) production, and aromatase, quinone reductase 2 (QR-2), and COX-1/-2 activities. Quercetin-3-O-β-d-glucoside (15) demonstrated inhibition against QR2 with an IC50 value of 3.84 μM, which confirmed kaempferol/quercetin glycosides as the active compounds to inhibit QR2. The compound also demonstrated NF-κB activity with an IC50 value of 33.6 μM. In addition, compounds 1, 2, 4, and 6 showed aromatase activity with IC50 values of 30.7, 32.3, 26.8, and 35.3 μM, respectively.
AB - Phytochemical investigation of the whole plant of Lepisorus contortus (Christ) Ching led to the isolation of five new phenylethanoid glycosides (1-5), each containing a caffeoyl group, a new flavonoid glycoside (10), and 14 known compounds (6-9 and 11-15, syringic acid, vanillic acid, phloretic acid, diplopterol, and β-sitosterol). This is the first report of phenylethanoid glycosides from the family Polypodiaceae. Compounds 1-15 were evaluated for their cancer chemopreventive potential based on their ability to inhibit tumor necrosis factor alpha (TNF-α)-induced NF-κB activity, nitric oxide (NO) production, and aromatase, quinone reductase 2 (QR-2), and COX-1/-2 activities. Quercetin-3-O-β-d-glucoside (15) demonstrated inhibition against QR2 with an IC50 value of 3.84 μM, which confirmed kaempferol/quercetin glycosides as the active compounds to inhibit QR2. The compound also demonstrated NF-κB activity with an IC50 value of 33.6 μM. In addition, compounds 1, 2, 4, and 6 showed aromatase activity with IC50 values of 30.7, 32.3, 26.8, and 35.3 μM, respectively.
UR - http://www.scopus.com/inward/record.url?scp=79952305457&partnerID=8YFLogxK
U2 - 10.1021/np100373f
DO - 10.1021/np100373f
M3 - Journal article
C2 - 21261296
AN - SCOPUS:79952305457
SN - 0163-3864
VL - 74
SP - 129
EP - 136
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 2
ER -
