Bioactive compounds from the fern Lepisorus contortus

Jian Hong Yang, Tamara P. Kondratyuk, Katherine C. Jermihov, Laura E. Marler, Xi Qiu, Yongsoo Choi, Hongmei Cao, Rui Yu, Megan Sturdy, Rong Huang, Ying Liu, Li Qin Wang, Andrew D. Mesecar, Richard B. Van Breemen, John M. Pezzuto, Harry H.S. Fong, Ye Gao Chen*, Hong Jie Zhang*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

32 Citations (Scopus)


Phytochemical investigation of the whole plant of Lepisorus contortus (Christ) Ching led to the isolation of five new phenylethanoid glycosides (1-5), each containing a caffeoyl group, a new flavonoid glycoside (10), and 14 known compounds (6-9 and 11-15, syringic acid, vanillic acid, phloretic acid, diplopterol, and β-sitosterol). This is the first report of phenylethanoid glycosides from the family Polypodiaceae. Compounds 1-15 were evaluated for their cancer chemopreventive potential based on their ability to inhibit tumor necrosis factor alpha (TNF-α)-induced NF-κB activity, nitric oxide (NO) production, and aromatase, quinone reductase 2 (QR-2), and COX-1/-2 activities. Quercetin-3-O-β-d-glucoside (15) demonstrated inhibition against QR2 with an IC50 value of 3.84 μM, which confirmed kaempferol/quercetin glycosides as the active compounds to inhibit QR2. The compound also demonstrated NF-κB activity with an IC50 value of 33.6 μM. In addition, compounds 1, 2, 4, and 6 showed aromatase activity with IC50 values of 30.7, 32.3, 26.8, and 35.3 μM, respectively.

Original languageEnglish
Pages (from-to)129-136
Number of pages8
JournalJournal of Natural Products
Issue number2
Early online date24 Jan 2011
Publication statusPublished - 25 Feb 2011

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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