TY - JOUR
T1 - Bioactive compounds from Vitex leptobotrys
AU - Pan, Wenhui
AU - Liu, Kanglun
AU - Guan, Yifu
AU - Tan, Ghee Teng
AU - Hung, Nguyen Van
AU - Cuong, Nguyen Manh
AU - Soejarto, D. Doel
AU - Pezzuto, John M.
AU - Fong, Harry H. S.
AU - Zhang, Hongjie
N1 - The work described in this paper was supported by NIH Grants 3U01TW001015-10S1 and 2U01TW001015-11A1 (administered by the Fogarty International Center as part of an International Cooperative Biodiversity Groups program, through funds from NIH, NSF, and Foreign Agricultural Service of the USDA), the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. HKBU262912), and Faculty Research Grant, Hong Kong Baptist University (FRG2/11-12/134).
PY - 2014/3/28
Y1 - 2014/3/28
N2 - A new lignan, vitexkarinol (1), as well as a known lignan, neopaulownin (2), a known chalcone, 3-(4-hydroxyphenyl)-1-(2,4,6-trimethoxyphenyl)-2-propen- 1-one (3), two known dehydroflavones, tsugafolin (4) and alpinetin (5), two known dipeptides, aurantiamide and aurantiamide acetate, a known sesquiterpene, vemopolyanthofuran, and five known carotenoid metabolites, vomifoliol, dihydrovomifoliol, dehydrovomifoliol, loliolide, and isololiolide, were isolated from the leaves and twigs of Vitex leptobotrys through bioassay-guided fractionation. The chalcone (3) was found to inhibit HIV-1 replication by 77% at 15.9 μM, and the two dehydroflavones (4 and 5) showed weak anti-HIV activity with IC50 values of 118 and 130 μM, respectively, while being devoid of cytotoxicity at 150 μM. A chlorophyll-enriched fraction of V. leptobotrys, containing pheophorbide a, was found to inhibit the replication of HIV-1 by 80% at a concentration of 10 μg/mL. Compounds 1 and 3 were further selected to be evaluated against 21 viral targets available at NIAID (National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA).
AB - A new lignan, vitexkarinol (1), as well as a known lignan, neopaulownin (2), a known chalcone, 3-(4-hydroxyphenyl)-1-(2,4,6-trimethoxyphenyl)-2-propen- 1-one (3), two known dehydroflavones, tsugafolin (4) and alpinetin (5), two known dipeptides, aurantiamide and aurantiamide acetate, a known sesquiterpene, vemopolyanthofuran, and five known carotenoid metabolites, vomifoliol, dihydrovomifoliol, dehydrovomifoliol, loliolide, and isololiolide, were isolated from the leaves and twigs of Vitex leptobotrys through bioassay-guided fractionation. The chalcone (3) was found to inhibit HIV-1 replication by 77% at 15.9 μM, and the two dehydroflavones (4 and 5) showed weak anti-HIV activity with IC50 values of 118 and 130 μM, respectively, while being devoid of cytotoxicity at 150 μM. A chlorophyll-enriched fraction of V. leptobotrys, containing pheophorbide a, was found to inhibit the replication of HIV-1 by 80% at a concentration of 10 μg/mL. Compounds 1 and 3 were further selected to be evaluated against 21 viral targets available at NIAID (National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA).
UR - http://www.scopus.com/inward/record.url?scp=84897375221&partnerID=8YFLogxK
U2 - 10.1021/np400779v
DO - 10.1021/np400779v
M3 - Journal article
C2 - 24404757
AN - SCOPUS:84897375221
SN - 0163-3864
VL - 77
SP - 663
EP - 667
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 3
ER -
